Evidence map›Paper›PMID 26553811›Full record

ArticleNucleic acids research2016

PASS2 database for the structure-based sequence alignment of distantly related SCOP domain superfamilies: update to version 5 and added features.

Arumugam Gandhimathi, Pritha Ghosh, Sridhar Hariharaputran, Oommen K Mathew, R Sowdhamini

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Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. PASS2: update of database of structure-based sequence alignments.Database : the journal of biological databases and curation · 2025
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Arumugam GandhimathiNational Centre for Biological Sciences (TIFR), GKVK Campus, Bangalore 560065, Karnataka, India.
Pritha GhoshNational Centre for Biological Sciences (TIFR), GKVK Campus, Bangalore 560065, Karnataka, India.
Sridhar HariharaputranNational Centre for Biological Sciences (TIFR), GKVK Campus, Bangalore 560065, Karnataka, India Bharathidasan University, Palkalainagar, Tiruchirapalli 620024, Tamilnadu, India.
Oommen K MathewNational Centre for Biological Sciences (TIFR), GKVK Campus, Bangalore 560065, Karnataka, India SASTRA University, Tirumalaisamudram, Thanjavur 613401, Tamil Nadu, India.
R SowdhaminiNational Centre for Biological Sciences (TIFR), GKVK Campus, Bangalore 560065, Karnataka, India mini@ncbs.res.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structure-based sequence alignment is an essential step in assessing and analysing the relationship of distantly related proteins. PASS2 is a database that records such alignments for protein domain superfamilies and has been constantly updated periodically. This update of the PASS2 version, named as PASS2.5, directly corresponds to the SCOPe 2.04 release. All SCOPe structural domains that share less than 40% sequence identity, as defined by the ASTRAL compendium of protein structures, are included. The current version includes 1977 superfamilies and has been assembled utilizing the structure-based sequence alignment protocol. Such an alignment is obtained initially through MATT, followed by a refinement through the COMPARER program. The JOY program has been used for structural annotations of such alignments. In this update, we have automated the protocol and focused on inclusion of new features such as mapping of GO terms, absolutely conserved residues among the domains in a superfamily and inclusion of PDBs, that are absent in SCOPe 2.04, using the HMM profiles from the alignments of the superfamily members and are provided as a separate list. We have also implemented a more user-friendly manner of data presentation and options for downloading more features. PASS2.5 version is available at http://caps.ncbs.res.in/pass2/.

Indexed as

Databases, ProteinProtein Structure, TertiarySequence AlignmentGene OntologyProteinsProteins

Identifiers

PMID26553811
PMCPMC4702857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.