Evidence map›Paper›PMID 26553697›Full record

ArticleCirculation. Cardiovascular interventions2015

Pulmonary artery denervation reduces pulmonary artery pressure and induces histological changes in an acute porcine model of pulmonary hypertension.

Alexander M K Rothman, Nadine D Arnold, William Chang, Oliver Watson, Andrew J Swift, Robin Condliffe, Charlie A Elliot, David G Kiely, S Kim Suvarna, Julian Gunn and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular interventions, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. New Drugs and Therapies in Pulmonary Arterial Hypertension.International journal of molecular sciences · 2023
    Review
  17. Review
  18. Review
  19. Current status of pulmonary artery denervation.Frontiers in cardiovascular medicine · 2022
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alexander M K RothmanFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.). a.rothman@sheffield.ac.uk.
Nadine D ArnoldFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
William ChangFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
Oliver WatsonFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
Andrew J SwiftFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
Robin CondliffeFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
Charlie A ElliotFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
David G KielyFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
S Kim SuvarnaFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
Julian GunnFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
Allan LawrieFrom the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).
Medtronic (United States) · US

Funding

British Heart Foundation FS/13/48/30453Medical Research Council G0800318Medical Research Council MC/PC/12022Medical Research Council MC_PC_12022Medical Research Council MR/K002406/1
6 · The paper itself

Abstract

backgroundPulmonary arterial hypertension is a devastating disease with high morbidity and mortality and limited treatment options. Recent studies have shown that pulmonary artery denervation improves pulmonary hemodynamics in an experimental model and in an early clinical trial. We aimed to evaluate the nerve distribution around the pulmonary artery, to determine the effect of radiofrequency pulmonary artery denervation on acute pulmonary hypertension induced by vasoconstriction, and to demonstrate denervation of the pulmonary artery at a histological level. METHODS AND

resultsHistological evaluation identified a circumferential distribution of nerves around the proximal pulmonary arteries. Nerves were smaller in diameter, greater in number, and located in closer proximity to the luminal aspect of the pulmonary arterial wall beyond the pulmonary artery bifurcation. To determine the effect of pulmonary arterial denervation acute pulmonary hypertension was induced in 8 pigs by intravenous infusion of thromboxane A2 analogue. Animals were assigned to either pulmonary artery denervation, using a prototype radiofrequency catheter and generator, or a sham procedure. Pulmonary artery denervation resulted in reduced mean pulmonary artery pressure and pulmonary vascular resistance and increased cardiac output. Ablation lesions on the luminal surface of the pulmonary artery were accompanied by histological and biochemical alteration in adventitial nerves and correlated with improved hemodynamic parameters.

conclusionsPulmonary artery denervation offers the possibility of a new treatment option for patients with pulmonary arterial hypertension. Further work is required to determine the long-term efficacy and safety.

Indexed as

Catheter AblationDenervationAcute DiseaseAnimalsAutonomic PathwaysBlood PressureCardiac OutputDisease Models, AnimalHemodynamicsHumansHypertension, PulmonaryPulmonary ArterySwineVascular ResistanceVasoconstrictionablation techniqueshypertensionnervous systempulmonarypulmonary arterypulmonary circulation

Identifiers

PMID26553697
PMCPMC4648184
OpenAlexW2157680326

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.