Evidence map›Paper›PMID 26553676›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

Public Health Impact After the Introduction of PsA-TT: The First 4 Years.

Fabien V K Diomandé, Mamoudou H Djingarey, Doumagoum M Daugla, Ryan T Novak, Paul A Kristiansen, Jean-Marc Collard, Kadidja Gamougam, Denis Kandolo, Nehemie Mbakuliyemo, Leonard Mayer and 10 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa.Proceedings of the National Academy of Sciences of the United States of America · 2018
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  18. Documenting the Results of a Successful Partnership: A New Meningococcal Vaccine for Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Fabien V K DiomandéCenters for Disease Control and Prevention, Atlanta, Georgia.
Mamoudou H DjingareyInter-country Support Team for West Africa, World Health Organization, Ouagadougou, Burkina Faso.
Doumagoum M DauglaCentre de Support en Santé International, N'Djamena, Chad.
Ryan T NovakCenters for Disease Control and Prevention, Atlanta, Georgia.
Paul A KristiansenWorld Health Organization, Collaborating Center for Reference and Research on Meningococci, Norwegian Institute of Public Health, Oslo, Norway.
Jean-Marc CollardCentre de Recherche Médicale et Sanitaire, Niamey, Niger.
Kadidja GamougamCentre de Support en Santé International, N'Djamena, Chad.
Denis KandoloInter-country Support Team for West Africa, World Health Organization, Ouagadougou, Burkina Faso.
Nehemie MbakuliyemoInter-country Support Team for West Africa, World Health Organization, Ouagadougou, Burkina Faso.
Leonard MayerCenters for Disease Control and Prevention, Atlanta, Georgia.
James StuartFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.
Thomas ClarkCenters for Disease Control and Prevention, Atlanta, Georgia.
Carol Tevi-BenissanWorld Health Organization, Regional Office for Africa, Brazzaville, Republic of Congo.
William A PereaDepartment of Pandemic and Epidemic Diseases, World Health Organization, Geneva, Switzerland.
Marie-Pierre PreziosiMeningitis Vaccine Project, PATH, Ferney-Voltaire, France Meningitis Vaccine Project, Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.
F Marc LaForceSerum Institute of India, Ltd, Pune.
Dominique CaugantCentre de Recherche Médicale et Sanitaire, Niamey, Niger.
Nancy MessonnierCenters for Disease Control and Prevention, Atlanta, Georgia.
Oladapo WalkerInter-country Support Team for West Africa, World Health Organization, Ouagadougou, Burkina Faso.
Brian GreenwoodFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010-2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated.

methodsThe new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence.

resultsPsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics.

conclusionsLessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings.

Indexed as

AdolescentAdultAfricaCarrier StateChildChild, PreschoolDisease Transmission, InfectiousFemaleHumansIncidenceInfantMaleMeningococcal InfectionsMeningococcal VaccinesTreatment OutcomeYoung AdultMenAfriVacMeningococcal VaccinesAfrica meningitis beltdisease incidencemeningococcal group APsA-TTvaccine evaluation framework

Identifiers

PMID26553676
PMCPMC4639484

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.