SynthesisNature reviews. Neurology2015
A novel diagnostic approach to patients with myoclonus.
Synthesis in Nature reviews. Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Myoclonus and cerebellar ataxia associated with COVID-19: a case report and systematic review.Journal of neurology · 2021Pooled it
- Diagnostic approach to paediatric movement disorders: a clinical practice guide.Developmental medicine and child neurology · 2021Guideline
- Diagnostic approach and treatment options for myoclonus.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Defining the Clinical Phenotypic Ground Truth: Expert Interrater Agreement in Hyperkinetic Movement Disorders.Movement disorders clinical practice · 2026Article
- Electrophysiological features and outcomes of post-infectious myoclonus-ataxia syndrome: a case report and literature review.Journal of medical case reports · 2026Review
- Benign Idiopathic Myoclonus: A New Clinical Entity?Movement disorders clinical practice · 2025Article
- Adult-Onset Myoclonus in a Large Urban Inpatient Setting: A Retrospective Cohort Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Adult-Onset Myoclonus: Comparisons and Contrasts in the Inpatient and Outpatient Settings.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Substantiating the Short Burst Duration in Cortical Myoclonus.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Myoclonus: Differential diagnosis and current management.Epilepsia open · 2024Review
- Tongue Biting Event in Patients with Sleep-Related Facial Mandibular Myoclonus: A Case Series Study.Nature and science of sleep · 2024Article
- The Muddle of Myoclonus: Many Guises, 2 Disciplines, Consensus Needed.Neurology. Clinical practice · 2023Article
- Article
- Pathogenic SCN5A Mutation and Thyrotoxicosis-Related Neurological Syndrome: Casual or Causal Relationship?Brain sciences · 2023Article
- Cortical myoclonic tremor after chimeric antigen receptor T-cell therapy.Journal of neurology · 2022Article
- Myoclonus in older Cavalier King Charles Spaniels.Journal of veterinary internal medicine · 2022Article
- Adult-onset mitochondrial movement disorders: a national picture from the Italian Network.Journal of neurology · 2022Article
- Myoclonus and other jerky movement disorders.Clinical neurophysiology practice · 2022Review
- Emerging role of clinical neurophysiology in the diagnosis of movement disorders.Clinical neurophysiology practice · 2022Article
- Movement Disorders Associated With Cerebral Artery Stenosis: A Nationwide Study.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myoclonus is a hyperkinetic movement disorder characterized by brief, involuntary muscular jerks. Recognition of myoclonus and determination of the underlying aetiology remains challenging given that both acquired and genetically determined disorders have varied manifestations. The diagnostic work-up in myoclonus is often time-consuming and costly, and a definitive diagnosis is reached in only a minority of patients. On the basis of a systematic literature review up to June 2015, we propose a novel diagnostic eight-step algorithm to help clinicians accurately, efficiently and cost-effectively diagnose myoclonus. The large number of genes implicated in myoclonus and the wide clinical variation of these genetic disorders emphasize the need for novel diagnostic techniques. Therefore, and for the first time, we incorporate next-generation sequencing (NGS) in a diagnostic algorithm for myoclonus. The initial step of the algorithm is to confirm whether the movement disorder phenotype is consistent with, myoclonus, and to define its anatomical subtype. The next steps are aimed at identification of both treatable acquired causes and those genetic causes of myoclonus that require a diagnostic approach other than NGS. Finally, other genetic diseases that could cause myoclonus can be investigated simultaneously by NGS techniques. To facilitate NGS diagnostics, we provide a comprehensive list of genes associated with myoclonus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.