Evidence map›Paper›PMID 26553493›Full record

ReviewSports medicine (Auckland, N.Z.)2015

Nutritional Strategies to Modulate Intracellular and Extracellular Buffering Capacity During High-Intensity Exercise.

Antonio Herbert Lancha Junior, Vitor de Salles Painelli, Bryan Saunders, Guilherme Giannini Artioli

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07737327 (The Acute Effects of Individually Timed Sodium Citrate Ingestion on Repeated Sprint Performance in Professional Female Soccer Players), which is not on this map. Cited by 65 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 10 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07737327 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Acute Effects of Individually Timed Sodium Citrate Ingestion on Repeated Sprint Performance in Professional Female Soccer Players: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

TypeinterventionalSponsorHacettepe UniversityRan2026 to 2027Enrolled20ConditionsExercise-Induced Fatigue, Athletic Performance, SoccerArmsSodium Citrate Oral Product, Placebo
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 10 syntheses or guidelines pooled it, 154 citations in OpenAlex.

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  9. Effects of sodium bicarbonate supplementation on exercise performance: an umbrella review.Journal of the International Society of Sports Nutrition · 2021
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  19. Caffeine and sodium bicarbonate supplementation alone or together improve karate performance.Journal of the International Society of Sports Nutrition · 2019
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Antonio Herbert Lancha JuniorLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, Av. Mello de Moraes, 65 Butanta, São Paulo, SP, 05508-030, Brazil. lanchajr@usp.br.
Vitor de Salles PainelliLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, Av. Mello de Moraes, 65 Butanta, São Paulo, SP, 05508-030, Brazil.
Bryan SaundersLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, Av. Mello de Moraes, 65 Butanta, São Paulo, SP, 05508-030, Brazil.
Guilherme Giannini ArtioliLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, Av. Mello de Moraes, 65 Butanta, São Paulo, SP, 05508-030, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intramuscular acidosis is a contributing factor to fatigue during high-intensity exercise. Many nutritional strategies aiming to increase intra- and extracellular buffering capacity have been investigated. Among these, supplementation of beta-alanine (~3-6.4 g/day for 4 weeks or longer), the rate-limiting factor to the intramuscular synthesis of carnosine (i.e. an intracellular buffer), has been shown to result in positive effects on exercise performance in which acidosis is a contributing factor to fatigue. Furthermore, sodium bicarbonate, sodium citrate and sodium/calcium lactate supplementation have been employed in an attempt to increase the extracellular buffering capacity. Although all attempts have increased blood bicarbonate concentrations, evidence indicates that sodium bicarbonate (0.3 g/kg body mass) is the most effective in improving high-intensity exercise performance. The evidence supporting the ergogenic effects of sodium citrate and lactate remain weak. These nutritional strategies are not without side effects, as gastrointestinal distress is often associated with the effective doses of sodium bicarbonate, sodium citrate and calcium lactate. Similarly, paresthesia (i.e. tingling sensation of the skin) is currently the only known side effect associated with beta-alanine supplementation, and it is caused by the acute elevation in plasma beta-alanine concentration after a single dose of beta-alanine. Finally, the co-supplementation of beta-alanine and sodium bicarbonate may result in additive ergogenic gains during high-intensity exercise, although studies are required to investigate this combination in a wide range of sports.

Indexed as

Dietary SupplementsAcidosisbeta-AlanineCalcium CompoundsCitratesEnergy MetabolismExerciseExtracellular FluidHumansHydrogen-Ion ConcentrationIntracellular FluidLactatesMuscle FatigueMuscle, SkeletalSodium BicarbonateSodium Citratebeta-AlanineCalcium Compoundscalcium lactateCitratesLactatesSodium BicarbonateSodium CitrateSodium Lactate

Identifiers

PMID26553493
PMCPMC4672007
OpenAlexW2140700167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.