ArticleJournal of general internal medicine2016
Opioid Prescribing at Hospital Discharge Contributes to Chronic Opioid Use.
Article in Journal of general internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
100 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Potential for Harm Associated with Discharge Opioids After Hospital Stay: A Systematic Review.Drugs · 2020Pooled it
- American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Opioid Minimization in Opioid-Naïve Patients.Anesthesia and analgesia · 2019Guideline
- Safe Opioid Prescribing for Acute Noncancer Pain in Hospitalized Adults: A Systematic Review of Existing Guidelines.Journal of hospital medicine · 2018Pooled it
- Perioperative Intravenous Dexamethasone Significantly Reduces Postoperative Opioid Requirement and Nausea After Unilateral Elective Hip Arthroscopy: A Randomized Double-blinded Placebo-controlled Trial.The American journal of sports medicine · 2024Trial
- Trial
- Association of Opioid Consumption Profiles After Hospitalization With Risk of Adverse Health Care Events.JAMA network open · 2021Trial
- Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting.Journal of general internal medicine · 2017Trial
- Digital Pills to Measure Opioid Ingestion Patterns in Emergency Department Patients With Acute Fracture Pain: A Pilot Study.Journal of medical Internet research · 2017Trial
- Examining Statewide Opioid Prescribing Limits and Prescription Drug Monitoring Program Mandates: Provider Compliance and Patient Outcomes.AJPM focus · 2026Article
- Comparative analysis of analgesic mechanisms in craniotomy pediatric patients: a scoping review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Clinical Decision Support to Increase Naloxone Co-prescribing from the Inpatient Setting.Journal of general internal medicine · 2026Observational
- Nudges for Naloxone in the Opioid Epidemic.Journal of general internal medicine · 2026Article
- Quality indicators for opioid stewardship interventions in hospital inpatient and emergency departments: a systematic review.Pain reports · 2025Review
- Evaluation of a hospital-based opioid stewardship program on high-risk opioid prescribing in a Canadian setting: an interrupted time series analysis.Addiction science & clinical practice · 2025Article
- The burden of acute pain in the U.S. in the wake of the opioid crisis.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Appropriateness of Prescribing Transmucosal Immediate-Release Fentanyl in the Emergency Room, During Hospitalization, and at Discharge: A Retrospective Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- A state-level analysis of macro-level factors associated with hospital readmissions.The European journal of health economics : HEPAC : health economics in prevention and care · 2024Article
- Prevalence and determinants of chronic pain and persistent opioid use after surgery: A review of systematic reviews.British journal of pain · 2024Article
- Variation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution.JAMA network open · 2024Article
- Targeted messaging to improve the adoption of clinical decision support for prescription drug monitoring program use.Journal of the American Medical Informatics Association : JAMIA · 2023Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic opioid therapy for chronic pain treatment has increased. Hospital physicians, including hospitalists and medical/surgical resident physicians, care for many hospitalized patients, yet little is known about opioid prescribing at hospital discharge and future chronic opioid use.
objectiveWe aimed to characterize opioid prescribing at hospital discharge among 'opioid naïve' patients. Opioid naïve patients had not filled an opioid prescription at an affiliated pharmacy 1 year preceding their hospital discharge. We also set out to quantify the risk of chronic opioid use and opioid refills 1 year post discharge among opioid naïve patients with and without opioid receipt at discharge.
designThis was a retrospective cohort study.
participantsFrom 1 January 2011 to 31 December 2011, 6,689 opioid naïve patients were discharged from a safety-net hospital. MAIN MEASURE: Chronic opioid use 1 year post discharge. KEY
resultsTwenty-five percent of opioid naïve patients (n = 1,688) had opioid receipt within 72 hours of discharge. Patients with opioid receipt were more likely to have diagnoses including neoplasm (6.3% versus 3.5%, p < 0.001), acute pain (2.7% versus 1.0 %, p < 0.001), chronic pain at admission (12.1% versus 3.3%, p < 0.001) or surgery during their hospitalization (65.1% versus 18.4%, p < 0.001) compared to patients without opioid receipt. Patients with opioid receipt were less likely to have alcohol use disorders (15.7% versus 20.7%, p < 0.001) and mental health disorders (23.9% versus 31.4%, p < 0.001) compared to patients without opioid receipt. Chronic opioid use 1 year post discharge was more common among patients with opioid receipt (4.1% versus 1.3%, p < 0.0001) compared to patients without opioid receipt. Opioid receipt was associated with increased odds of chronic opioid use (AOR = 4.90, 95% CI 3.22-7.45) and greater subsequent opioid refills (AOR = 2.67, 95% CI 2.29-3.13) 1 year post discharge compared to no opioid receipt.
conclusionOpioid receipt at hospital discharge among opioid naïve patients increased future chronic opioid use. Physicians should inform patients of this risk prior to prescribing opioids at discharge.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.