ArticleRespiratory medicine2015
Association of pulse wave velocity with total lung capacity: A cross-sectional analysis of the BOLD London study.
Article in Respiratory medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- A cohort study of forced vital capacity, airway obstruction, and survival in the multinational Burden of Obstructive Lung Disease study.International journal of epidemiology · 2026Article
- Prevalence and determinants of vascular aging in Austria - a holistic view: the LEAD study.Journal of hypertension · 2026Observational
- Lung capacity is a determinant of cardiovascular disease and myocardial infarction.Respiratory research · 2026Article
- Article
- Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study.BMJ open respiratory research · 2025Article
- The interaction effect of grip strength and lung function (especially FVC) on cardiovascular diseases: a prospective cohort study in Jiangsu Province, China.Journal of geriatric cardiology : JGC · 2022Article
- Incremental prognostic value of arterial elastance in mild-to-moderate idiopathic pulmonary fibrosis.The international journal of cardiovascular imaging · 2022Article
- Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study.Respiratory research · 2022Article
- The impact of COPD on polyneuropathy: results from the German COPD cohort COSYCONET.Respiratory research · 2020Article
- Relationship between pulmonary function and brachial-ankle pulse wave velocity in coal miners in northern China.Journal of thoracic disease · 2019Article
- Does Poorer Pulmonary Function Accelerate Arterial Stiffening?: A Cohort Study With Repeated Measurements of Carotid-Femoral Pulse Wave Velocity.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Environmental exposures and systemic hypertension are risk factors for decline in lung function.Thorax · 2018Article
- Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD.BMC pulmonary medicine · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundLow lung function, measured using spirometry, has been associated with mortality from cardiovascular disease, but whether this is explained by airflow obstruction or restriction is a question that remains unanswered.
objectivesTo assess the association of total lung capacity (TLC), forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) with several cardio-metabolic and inflammatory markers.
methodsIn the follow up of the Burden of Lung Disease (BOLD) study in London, acceptable post-bronchodilator spirometric, pulse rate, pulse wave velocity and blood pressure data were obtained from 108 participants. Blood samples for measurement of cardio-metabolic and inflammatory markers were also collected from these participants. Association of lung function and volume with the different biomarkers was examined in multivariable linear regression models adjusted for potential confounders.
resultsFollowing adjustment for age, sex, height, and ethnicity, TLC (adjusted coefficient = -1.53; 95% CI: -2.57, -0.49) and FVC (adjusted coefficient = -2.66; 95% CI: -4.98, -0.34) were inversely associated with pulse wave velocity, and further adjustment for smoking status, pack-years and body mass index (BMI) did not materially change these results. FEV1 was inversely associated with systolic blood pressure, and adjustment for smoking status, pack-years and BMI made this association stronger (adjusted coefficient = -9.47; 95% CI: -15.62, -3.32).
conclusionThe inverse association of pulse wave velocity, which is a marker of cardiovascular disease, with TLC suggests that the association of the former with low FVC is independent of airflow obstruction. The association between FEV1 with systolic blood pressure after adjustment for FVC suggests an association with airflow obstruction rather than with restricted spirometry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.