ArticleAnnals of intensive care2015
Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation?
Article in Annals of intensive care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Fluid-electrolyte homeostasis requires histone deacetylase function.JCI insight · 2020Pooled it
- Hyponatremia in Acute Stroke: A Comparative Study of Ischemic and Hemorrhagic Stroke Subtypes.Cureus · 2025Article
- Persistent Polyuria in Severe Hyponatremia Secondary to Beer Potomania and Hypokalemia: A Case Report.Cureus · 2025Article
- Intensive Care Management of Severe Hyponatraemia-An Observational Study.Medicina (Kaunas, Lithuania) · 2024Observational
- Use of Venous Excess UltraSound (VExUS) score in hyponatraemia management in critically ill patient.BMJ case reports · 2022Article
- High Urinary Sodium Concentrations in Severe SIADH: Case Reports of 2 Patients and Literature Review.Frontiers in medicine · 2022Article
- Diagnostic Modalities in Critical Care: Point-of-Care Approach.Diagnostics (Basel, Switzerland) · 2021Review
- Clinical spectrum and risk factors for mortality among seawater and freshwater critically ill drowning patients: a French multicenter study.Critical care (London, England) · 2021Article
- Hemodialysis treatment in patients with severe electrolyte disorders: Management of hyperkalemia and hyponatremia.Hemodialysis international. International Symposium on Home Hemodialysis · 2020Review
- The 2014 updated version of the Confusion Assessment Method for the Intensive Care Unit compared to the 5th version of the Diagnostic and Statistical Manual of Mental Disorders and other current methods used by intensivists.Annals of intensive care · 2018Article
- From renal salt wasting to SIADH.BMJ case reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia is a common electrolyte derangement in the setting of the intensive care unit. Life-threatening neurological complications may arise not only in case of a severe (<120 mmol/L) and acute fall of plasma sodium levels, but may also stem from overly rapid correction of hyponatremia. Additionally, even mild hyponatremia carries a poor short-term and long-term prognosis across a wide range of conditions. Its multifaceted and intricate physiopathology may seem deterring at first glance, yet a careful multi-step diagnostic approach may easily unravel the underlying mechanisms and enable physicians to adopt the adequate measures at the patient's bedside. Unless hyponatremia is associated with obvious extracellular fluid volume increase such as in heart failure or cirrhosis, hypertonic saline therapy is the cornerstone of the therapeutic of profound or severely symptomatic hyponatremia. When overcorrection of hyponatremia occurs, recent data indicate that re-lowering of plasma sodium levels through the infusion of hypotonic fluids and the cautious use of desmopressin acetate represent a reasonable strategy. New therapeutic options have recently emerged, foremost among these being vaptans, but their use in the setting of the intensive care unit remains to be clarified.
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Registered trials
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