SynthesisBMC ophthalmology2015
Association between a vascular endothelial growth factor gene polymorphism (rs2146323) and diabetic retinopathy: a meta-analysis.
Synthesis in BMC ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Sex- and age-specific associations ofAnnals of medicine · 2026Article
- Associations of VEGF Polymorphisms With Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2023Article
- Association between theOpen life sciences · 2023Article
- Investigating the Mechanism of Rhizoma Coptidis-Eupatorium fortunei Medicine in the Treatment of Type 2 Diabetes Based on Network Pharmacology and Molecular Docking.BioMed research international · 2022Article
- Association of vascular endothelial growth factor expression and polymorphisms with the risk of gestational diabetes mellitus.Journal of clinical laboratory analysis · 2019Article
- VEGF-A gene polymorphisms and responses to intravitreal ranibizumab treatment in patients with diabetic macular edema.International ophthalmology · 2018Article
- Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan.Scientific reports · 2018Article
- Candidate gene studies of diabetic retinopathy in human.Molecular biology reports · 2016Review
- Biomarkers of Diabetic Retinopathy.Current diabetes reports · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVascular endothelial growth factor (VEGF) is thought to play an important role in the pathogenesis of diabetic retinopathy (DR). Previous studies have associated the VEGF rs2146323 polymorphism with the risk of DR. However, the results of these studies are inconsistent. A meta-analysis was performed to evaluate the association between the VEGF rs2146323 polymorphism and the risk of DR.
methodsThe PubMed, EMBASE, Web of Science and Google Scholar literature databases until March 2015 were searched. The differences in the studies were expressed in the form of an odds ratio (OR) and the corresponding 95% confidence interval (CI). Heterogeneity among the studies was tested using the I(2) statistic based on the Q test.
resultsA total of four studies (598 cases and 709 controls) were included in the meta-analysis. A significant association was found involving the rs2146323 polymorphism in the dominant model (CA + AA VS. CC) (OR = 1.38, CI = 1.10-1.72, P = 0.005) and the co-dominant model (CA VS. CC) (OR = 1.37, CI = 1.08-1.74, P = 0.008).
conclusionsOur meta-analysis confirmed the association between the VEGF rs2146323 polymorphism and the risk of DR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.