ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Increased Prevalence of Controlled Viremia and Decreased Rates of HIV Drug Resistance Among HIV-Positive People Who Use Illicit Drugs During a Community-wide Treatment-as-Prevention Initiative.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- The impact of methadone maintenance therapy on access to regular physician care regarding hepatitis C among people who inject drugs.PloS one · 2018Trial
- Safer supply deprescribing during a toxic drug poisoning crisis in Vancouver, Canada.Drug and alcohol dependence · 2026Article
- Self-reported cannabis use to manage opioid withdrawal symptoms and reductions in opioid use among people who use unregulated opioids: a cross-sectional analysis.Journal of cannabis research · 2026Article
- Injecting drugs alone during an overdose crisis in Vancouver, Canada.Harm reduction journal · 2022Article
- HIV and Incarceration: Implications for HIV-Positive People Who Use Illicit Drugs During a Seek, Test, Treat, and Retain Initiative in Canada.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2022Article
- Periods of Homelessness Linked to Higher VACS Index Among HIV-Positive People Who Use Drugs.AIDS and behavior · 2022Article
- Assessing the Temporality Between Transitions onto Opioid Agonist Therapy and Engagement with Antiretroviral Therapy in a Cohort of HIV-Positive People Who Use Opioids Daily.AIDS and behavior · 2022Article
- Inability to access primary care clinics among people who inject drugs in a Canadian health care setting.Canadian family physician Medecin de famille canadien · 2021Article
- Sociodemographic, Ecological, and Spatiotemporal Factors Associated with Human Immunodeficiency Virus Drug Resistance in Florida: A Retrospective Analysis.The Journal of infectious diseases · 2021Article
- Withdrawal-associated injury site pain prevalence and correlates among opioid-using people who inject drugs in Vancouver, Canada.Drug and alcohol dependence · 2020Article
- Article
- The effect of injecting alone on the use of drug checking services among people who inject drugs.The International journal on drug policy · 2020Article
- Criminal Justice System Involvement as a Risk Factor for Detectable Plasma HIV Viral Load in People Who Use Illicit Drugs: A Longitudinal Cohort Study.AIDS and behavior · 2019Article
- Engagement in Maximally-Assisted Therapy and Adherence to Antiretroviral Therapy Among a Cohort of Indigenous People Who Use Illicit Drugs.AIDS and behavior · 2019Article
- Prevalence and Correlates of Reporting Difficulty Taking Antiretroviral Treatment Among HIV-Positive Illicit Drug Users in Vancouver, Canada: A Longitudinal Analysis.AIDS and behavior · 2019Article
- Predictors of Antiretroviral Adherence Self-efficacy Among People Living With HIV/AIDS in a Canadian Setting.Journal of acquired immune deficiency syndromes (1999) · 2019Observational
- Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis.PloS one · 2019Article
- High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis.Addiction (Abingdon, England) · 2018Article
- Substance Use and Adherence to Antiretroviral Therapy: What Is Known and What Is Unknown.Current infectious disease reports · 2018Review
- Social and structural factors associated with greater time with a plasma HIV-1 RNA viral load above log10(1500) copies/ml among illicit drug users.AIDS (London, England) · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundAlthough treatment-as prevention (TasP) is a new cornerstone of global human immunodeficiency virus (HIV)-AIDS strategies, its effect among HIV-positive people who use illicit drugs (PWUD) has yet to be evaluated. We sought to describe longitudinal trends in exposure to antiretroviral therapy (ART), plasma HIV-1 RNA viral load (VL) and HIV drug resistance during a community-wide TasP intervention.
methodsWe used data from the AIDS Care Cohort to Evaluate Exposure to Survival Services study, a prospective cohort of HIV-positive PWUD linked to HIV clinical monitoring records. We estimated longitudinal changes in the proportion of individuals with VL <50 copies/mL and rates of HIV drug resistance using generalized estimating equations (GEE) and extended Cox models.
resultsBetween 1 January 2006 and 30 June 2014, 819 individuals were recruited and contributed 1 or more VL observation. During that time, the proportion of individuals with nondetectable VL increased from 28% to 63% (P < .001). In a multivariable GEE model, later year of observation was independently and positively associated with greater likelihood of nondetectable VL (adjusted odds ratio = 1.20 per year; P < .001). Although the proportion of individuals on ART increased, the incidence of HIV drug resistance declined (adjusted hazard ratio = 0.78 per year; P = .011).
conclusionsWe observed significant improvements in several measures of exposure to ART and virologic status, including declines in HIV drug resistance, in this large long-running community-recruited cohort of HIV-seropositive illicit drug users during a community-wide ART expansion intervention. Our findings support continued efforts to scale up ART coverage among HIV-positive PWUD.
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