Evidence map›Paper›PMID 26552984›Full record

ArticleAntimicrobial agents and chemotherapy2016

fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin.

Karla de Oliveira Pelegrino, Juliana Coutinho Campos, Suely Carlos Ferreira Sampaio, Karina Lezirovitz, Bruna Mara Seco, Mayne de Oliveira Pereira, Darlan Augusto da Costa Rocha, Thomas Jové, Antonio Carlos Nicodemo, Jorge Luiz Mello Sampaio

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Karla de Oliveira PelegrinoSchool of Medicine, Infectious Diseases Department, University of São Paulo, São Paulo, SP, Brazil.
Juliana Coutinho CamposClinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
Suely Carlos Ferreira SampaioDepartamento de Microbiologia e Imunologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Karina LezirovitzSchool of Medicine, Otorhinolaryngology Lab/LIM32, Hospital das Clínicas, University of São Paulo, São Paulo, SP, Brazil.
Bruna Mara SecoClinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
Mayne de Oliveira PereiraClinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
Darlan Augusto da Costa RochaClinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
Thomas JovéUniversité Limoges, INSERM, CHU Limoges, UMR_S 1092, Limoges, France.
Antonio Carlos NicodemoSchool of Medicine, Infectious Diseases Department, University of São Paulo, São Paulo, SP, Brazil.
Jorge Luiz Mello SampaioClinical Analysis and Toxicology Department, School of Pharmacy, University of São Paulo, São Paulo, SP, Brazil Fleury Medicine and Health, Microbiology Department, São Paulo, SP, Brazil sampaio@usp.br.
Universidade de São Paulo · BRFleury S.A. (Brazil) · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInserm · FRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we demonstrate that the fosI gene encodes a predicted small protein with 134 amino acids and determines reduced susceptibility to fosfomycin. It raised the MIC from 0.125 to 6 μg/ml when the pBRA100 plasmid was introduced into Escherichia coli TOP10 and to 16 μg/ml when the gene was cloned into the pBC_SK(-) vector and expressed in E. coli TOP10.

Indexed as

IntegronsAmino Acid SequenceAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliFosfomycinGene ExpressionMicrobial Sensitivity TestsMolecular Sequence DataPlasmidsSequence AlignmentTransformation, BacterialAnti-Bacterial AgentsFosfomycin

Identifiers

PMID26552984
PMCPMC4704179
OpenAlexW2134725197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.