Evidence map›Paper›PMID 26552935›Full record

ArticleInternational psychogeriatrics2016

Insomnia is associated with suicide attempt in middle-aged and older adults with depression.

Daniel B Kay, Alexandre Y Dombrovski, Daniel J Buysse, Charles F Reynolds, Amy Begley, Katalin Szanto

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in International psychogeriatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04986007 (Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04986007 naterminatednot on this mapstarted 2021, after this paper: background citation

Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults (ANSWERS-OA): A Pilot, Open-Label, Randomized Controlled Trial of Digital Cognitive Behavioral Therapy for Insomnia

TypeinterventionalSponsorMICHAEL A GRANDNERRan2021 to 2025Enrolled23ConditionsSleep Initiation and Maintenance Disorders, Suicidal IdeationArmsDigital Cognitive Behavioral Therapy for Insomnia
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. You lack the season of all natures, sleep.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Insomnia in Older Adults.Current geriatrics reports · 2019
    Article
  17. Suicide in the elderly: a 37-years retrospective study.Acta bio-medica : Atenei Parmensis · 2019
    Article
  18. Perspectives on the Management of Vascular Depression.The American journal of psychiatry · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniel B KayDepartment of Psychiatry,University of Pittsburgh,Pittsburgh,Pennsylvania,15213,USA.
Alexandre Y DombrovskiDepartment of Psychiatry,University of Pittsburgh,Pittsburgh,Pennsylvania,15213,USA.
Daniel J BuysseDepartment of Psychiatry,University of Pittsburgh,Pittsburgh,Pennsylvania,15213,USA.
Charles F ReynoldsDepartment of Psychiatry,University of Pittsburgh,Pittsburgh,Pennsylvania,15213,USA.
Amy BegleyDepartment of Psychiatry,University of Pittsburgh,Pittsburgh,Pennsylvania,15213,USA.
Katalin SzantoDepartment of Psychiatry,University of Pittsburgh,Pittsburgh,Pennsylvania,15213,USA.
University of Pittsburgh · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
RESEARCH TRAINING COREP60MD000207 · NIMHD · UNIV OF MARYLAND, COLLEGE PARK · PI THOMAS, STEPHEN B. · 2002 to 2011
$10.8M
Short Term Variability in Affect and Rest Activity Rhythms in Long Term Chronic and Highly Variable Suicidal Ideation in Depressed Older AdultsR01MH085651 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANGA CSILLA GALFALVY, Swathi Gujral · 2010 to 2026
$9.6M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F · 2011 to 2015
$8.3M
Reward Learning in Late-Life Suicidal BehaviorR01MH100095 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Alexandre Y. Dombrovski · 2014 to 2026
$6.8M
Translational Research Training in Sleep MedicineT32HL082610 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, PETER L FRANZEN · 2007 to 2026
$5.8M
Cognitive and Affective Neuroscience of Decision-Making in Late-Life SuicideK23MH086620 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOMBROVSKI, ALEXANDRE Y. · 2009 to 2013
$853k
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1TR000005NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1RR024153NHLBI NIH HHS HL082610NHLBI NIH HHS T32 HL082610NIMHD NIH HHS P60 MD000207NIMH NIH HHS K23 MH086620NIMH NIH HHS P30 MH090333NIMH NIH HHS R01 MH085651NIMH NIH HHS R01 MH100095
6 · The paper itself

Abstract

backgroundInsomnia increases in prevalence with age, is strongly associated with depression, and has been identified as a risk factor for suicide in several studies. The aim of this study was to determine whether insomnia severity varies between those who have attempted suicide (n = 72), those who only contemplate suicide (n = 28), and those who are depressed but have no suicidal ideation or attempt history (n = 35).

methodsParticipants were middle-aged and older adults (age 44-87, M = 66 years) with depression. Insomnia severity was measured as the sum of the early, middle, and late insomnia items from the Hamilton Rating Scale for Depression. General linear models examined relations between group status as the independent variable and insomnia severity as the dependent variable.

resultsThe suicide attempt group suffered from more severe insomnia than the suicidal ideation and non-suicidal depressed groups (p < 0.05). Differences remained after adjusting for potential confounders including demographics, cognitive ability, alcohol dependence in the past month, severity of depressed mood, anxiety, and physical health burden. Moreover, greater insomnia severity in the suicide attempt group could not be explained by interpersonal difficulties, executive functioning, benzodiazepine use, or by the presence of post-traumatic stress disorder.

conclusionsOur results suggest that insomnia may be more strongly associated with suicidal behavior than with the presence of suicidal thoughts alone. Accordingly, insomnia is a potential treatment target for reducing suicide risk in middle-aged and older adults.

Indexed as

Suicidal IdeationAdultAgedAged, 80 and overCase-Control StudiesCross-Sectional StudiesDepressionFemaleHumansMaleMiddle AgedPennsylvaniaSeverity of Illness IndexSleep Initiation and Maintenance DisordersSuicide, Attempteddepressioninsomnia symptomssuicidal ideationsuicide attempt

Identifiers

PMID26552935
PMCPMC4808421
OpenAlexW2193105650

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.