Evidence map›Paper›PMID 26552895›Full record

ArticleJournal of pediatric surgery2016

Development of an endoluminal intestinal attachment for a clinically applicable distraction enterogenesis device.

Farokh R Demehri, Brent Utter, Jennifer J Freeman, Yumi Fukatsu, Jonathan Luntz, Diann Brei, Daniel H Teitelbaum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Submucosal Hydrogel for Spring-Mediated Intestinal Lengthening.Journal of biomedical materials research. Part A · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Mechanisms for intestinal regeneration.Current opinion in pediatrics · 2018
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Farokh R DemehriSection of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, USA.
Brent UtterDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, USA.
Jennifer J FreemanSection of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, USA.
Yumi FukatsuSection of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, USA.
Jonathan LuntzDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, USA.
Diann BreiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, USA.
Daniel H TeitelbaumSection of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, USA. Electronic address: dttlbm@umich.edu.

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
UNIVERSITY OF MICHIGAN PEDIATRIC DEVICE CONSORTIUM (M-PED)P50FD003787 · FDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GEIGER, JAMES D · 2009 to 2015
$6.0M
TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTESR01AI044076 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TEITELBAUM, DANIEL H · 2004 to 2014
$3.2M
A Novel Catheter Enterogenesis Device to Treat Short Bowel SyndromeR44DK085765 · NIDDK · MC3, INC. · PI TEITELBAUM, DANIEL H, WONG, PHILIP M · 2011 to 2012
$967k
FDA HHS 2-P50-FD-003787-03FDA HHS P50 FD003787NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1TR000433NIAID NIH HHS R01 AI044076NIDDK NIH HHS NIH 2R44DK085765-02NIDDK NIH HHS R44 DK085765
6 · The paper itself

Abstract

purposePrevious methods of distraction enterogenesis have relied upon blind-ending intestinal segments or transmural device fixation, requiring multiple operations and potential bowel injury. We hypothesized that using a novel attachment would allow reversible device coupling to the luminal bowel surface, achieving effective endoluminal distraction.

methodsA telescopic hydraulic device was designed with latex balloon attachments covered with high-friction mesh and a dilating fenestrated elastic mask (DFM attachment), allowing mesh-to-mucosa contact only with inflation. Yorkshire pigs underwent jejunal Roux-en-Y limb creation and device placement via jejunostomy. Devices underwent 3 cycles of balloon inflation and hydraulic extension/retraction per day for 7 days and then explanted and studied for efficacy.

resultsDFM attachment allowed reversible, high-strength endoluminal coupling without tissue injury or reduction in bowel perfusion. After 7 day implant, distracted bowel achieved a 44 ± 2% increase in length vs. fed, nondistracted bowel, corresponding to a gain of 7.1 ± 0.3 cm. Distracted bowel demonstrated increased epithelial cell proliferation vs. control bowel. Attachment sites demonstrated villus flattening, increased crypt depth, thicker muscularis mucosa, and unchanged muscularis propria thickness vs.

conclusionNovel high-strength, reversible attachments enabled fully endoluminal distraction enterogenesis, achieving length gains comparable to open surgical techniques. This approach may allow development of clinically applicable technology for SBS treatment.

Indexed as

Tissue Expansion DevicesAnimalsFemaleJejunostomyJejunumShort Bowel SyndromeSwineTissue ExpansionDistraction enterogenesisMechanotransductionPediatric deviceShort bowel syndrome

Identifiers

PMID26552895
PMCPMC4713322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.