ArticleBMC complementary and alternative medicine2015
Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 89 citations in OpenAlex.
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- Chemical Profile ofMolecules (Basel, Switzerland) · 2022Article
- Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects.Molecules (Basel, Switzerland) · 2022Article
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- Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts ofNatural product communications · 2022Article
- GenusPlants (Basel, Switzerland) · 2022Review
- Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade.Journal of tropical medicine · 2022Review
- Potential antioxidant effects of Narcissus tazetta phenolic compounds against cadmium chloride-induced hepatotoxicity in Swiss albino mice.Environmental science and pollution research international · 2021Article
- Flavonoid-rich fraction attenuates permethrin-induced toxicity by modulating ROS-mediated hepatic oxidative stress and mitochondrial dysfunction ex vivo and in vivo in rat.Environmental science and pollution research international · 2021Article
- The Protective Impact ofFrontiers in veterinary science · 2021Article
- Methanol leaf extract ofVeterinary world · 2020Article
- Aqueous Partition of Methanolic Extract ofNutrients · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFlavonoids and other polyphenols play a protective role in liver diseases and possess a high antioxidant capacity.
objectiveTo compare and evaluate the antioxidant and hepatotoprotective activities of 4 deserts plants, Fagonia indica Burm. f., Calotropis procera R.Br., Zygophylum hamiense Schweinf. and Salsola imbricata Forssk. in correlation to their composition especially their phenolic content.
methodsThe influence of extracting solvent on total phenolic and flavonoidal contents was assessed spectrophotometrically. The flavonoid and other polyphenolic components of the methanol extracts were analyzed by RP-HPLC. DPPH radical scavenging potential of the different extracts was estimated. The hepatoprotective and antioxidant activities of the extracts against CCl4-induced hepatotoxicity in mice were evaluated.
resultsThe flavonol quercitrin and rosmarinic acid were major in the F. indica, C. procera and S. imbricata samples, while rutin prevailed in that of Z. hamiense. The ethanolic and methanolic extracts showed noticeable DPPH radical-scavenging activity as compared to ascorbic acid. Assessment of liver enzymes revealed that oral administration of the extracts did not show any evidence of hepatotoxicity. Moreover, protection against CCl4-induced liver damage was evident upon administration of three plants extracts namely, F. indica, C. procera and S. imbricata.
conclusionOverall, hepatotoxicity induced by CCl4 was effectively prevented by the three plants extracts through scavenging of free radicals and by boosting the antioxidant capacity of the liver. The protective effect of the plants could be attributed to their high quercitrin and rosmarinic acid contents.
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