ArticleMolecular psychiatry2016
A novel approach to PTSD modeling in rats reveals alternating patterns of limbic activity in different types of stress reaction.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 95 citations in OpenAlex.
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- Behavioral phenotype analysis highlights sleep heterogeneity and brain cellular activations in a mouse model of PTSD.Neurobiology of stress · 2026Article
- Transcriptomic profiles of susceptibility and resilience to stress in the amygdala and hippocampus of male rats.Neurobiology of stress · 2025Article
- Review
- Interindividual and sex differences in resilience and vulnerability to post-traumatic stress disorder (PTSD): insights from animal models.Biology of sex differences · 2025Review
- Effects of TrkB-related induced metaplasticity within the BLA on anxiety, extinction learning, and plasticity in BLA-modulated brain regions.Behavioral and brain functions : BBF · 2025Article
- Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Analysis of behavioral flow resolves latent phenotypes.Nature methods · 2024Article
- Behavioural profiling following acute stress uncovers associations with future stress sensitivity and past childhood abuse.European journal of psychotraumatology · 2024Article
- Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat.The international journal of neuropsychopharmacology · 2023Article
- Early- and late-phase changes of brain activity and early-phase neuromodulation in the posttraumatic stress disorder rat model.Neurobiology of stress · 2023Article
- Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.Neuroscience and biobehavioral reviews · 2023Review
- Steady electrocorticogram characteristics predict specific stress-induced behavioral phenotypes.Frontiers in neuroscience · 2023Article
- Aberrant ventral dentate gyrus structure and function in trauma susceptible mice.Translational psychiatry · 2022Article
- The role of hippocampal CaMKII in resilience to trauma-related psychopathology.Neurobiology of stress · 2022Article
- Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene.Translational psychiatry · 2022Article
- Anhedonia in Posttraumatic Stress Disorder: Prevalence, Phenotypes, and Neural Circuitry.Current topics in behavioral neurosciences · 2022Review
- Reducing glutamic acid decarboxylase in the dorsal dentate gyrus attenuates juvenile stress induced emotional and cognitive deficits.Neurobiology of stress · 2021Article
- Impact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake.Neurobiology of stress · 2021Article
- αCaMKII in the lateral amygdala mediates PTSD-Like behaviors and NMDAR-Dependent LTD.Neurobiology of stress · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human reactions to trauma exposure are extremely diverse, with some individuals exhibiting only time-limited distress and others qualifying for posttraumatic stress disorder diagnosis (PTSD). Furthermore, whereas most PTSD patients mainly display fear-based symptoms, a minority of patients display a co-morbid anhedonic phenotype. We employed an individual profiling approach to model these intriguing facets of the psychiatric condition in underwater-trauma exposed rats. Based on long-term assessments of anxiety-like and anhedonic behaviors, our analysis uncovered three separate phenotypes of stress response; an anxious, fear-based (38%), a co-morbid, fear-anhedonic (15%), and an exposed-unaffected group (47%). Immunohistochemical assessments for cellular activation (c-Fos) and activation of inhibition (c-Fos+GAD67) revealed a differential involvement of limbic regions and distinct co-activity patterns for each of these phenotypes, validating the behavioral categorization. In accordance with recent neurocognitive hypotheses for posttraumatic depression, we show that enhanced pretrauma anxiety predicts the progression of posttraumatic anhedonia only in the fear-anhedonic phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.