ArticleInflammation2016
Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury.
Article in Inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Unveiling the impact of bisphenol a exposure on gene expression and immune response in diabetic nephropathy through integrative toxicogenomics and molecular dynamics approaches.Diabetology & metabolic syndrome · 2025Article
- Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells.BMC nephrology · 2025Article
- Role and Mechanisms of Tyro3 in Podocyte Biology and Glomerular Disease.Kidney diseases (Basel, Switzerland) · 2024Review
- MicroRNAs in septic acute kidney injury.Burns & trauma · 2023Article
- Inhibition of microRNA-665 Alleviates Septic Acute Kidney Injury by Targeting Bcl-2.Journal of healthcare engineering · 2022Article
- Urinary proteome analysis of acute kidney injury in post-cardiac surgery patients using enrichment materials with high-resolution mass spectrometry.Frontiers in bioengineering and biotechnology · 2022Article
- Bioprotective and Functional Effect of Carnosine on Sepsis Induced Renal Damage in Male Albino Rat Model through Targeting IL-1β and TNF-α Production.Doklady. Biochemistry and biophysics · 2021Article
- Article
- Role of emerging vitamin K‑dependent proteins: Growth arrest‑specific protein 6, Gla‑rich protein and periostin (Review).International journal of molecular medicine · 2021Review
- Renal Tissue Damage Induced by Acute Kidney Injury in Sepsis Rat Model Is Inhibited by Cynaropicrin via IL-1β and TNF-α Down-Regulation.Doklady. Biochemistry and biophysics · 2021Article
- Effect of ATM on inflammatory response and autophagy in renal tubular epithelial cells in LPS-induced septic AKI.Experimental and therapeutic medicine · 2019Article
- Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway.International journal of molecular medicine · 2019Article
- Vitamin K Dependent Proteins in Kidney Disease.International journal of molecular sciences · 2019Review
- Gas6/TAM Axis in Sepsis: Time to Consider Its Potential Role as a Therapeutic Target.Disease markers · 2019Review
- Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial HyperpermeabilityFrontiers in pharmacology · 2019Article
- Protective Effects of a Rho Kinase Inhibitor on Paraquat-Induced Acute Lung Injuries in Rats.Inflammation · 2018Article
- Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats.Molecular medicine reports · 2018Article
- Pterostilbene attenuates acute kidney injury in septic mice.Experimental and therapeutic medicine · 2018Article
- Klotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy.OncoTargets and therapy · 2018Article
- Protective Effects of Pterostilbene Against Myocardial Ischemia/Reperfusion Injury in Rats.Inflammation · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a serious complication of sepsis, which has a high mortality rate. Growth arrest-specific protein 6 (Gas6), the protein product of the growth arrest specific gene 6, has been shown to have an anti-apoptotic effect as well as pro-survival capability. Here, we investigated the effects of Gas6 on sepsis-associated AKI in mice subjected to cecal ligation and puncture (CLP). We found that the administration of rmGas6 significantly reduced serum urea nitrogen and creatinine and improved the survival of septic mice. Furthermore, the renal pathological damage induced by CLP was attenuated by rmGas6 treatment. Finally, rmGas6 reduced the renal tissue apoptotic index and the expression of Bax, while it upregulated the expression of Bcl-2. The data suggest that rmGas6 might be used as a potential therapeutic agent for sepsis-induced AKI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.