ArticlePLoS genetics2015
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) Males.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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91 citing papers in PubMed, 217 citations in OpenAlex.
- Development and Genetic Monitoring of a Putatively Thiamine Deficiency Complex Tolerant Atlantic Salmon Broodstock.Ecology and evolution · 2026Article
- An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan.Nature communications · 2026Article
- A large-effect locus underlies migration timing in North American Atlantic salmon (Salmo salar).Scientific reports · 2026Article
- Early life exploration behaviour and life-history loci are colocalized in an adaptive genomic hotspot in Atlantic salmon.The Journal of animal ecology · 2026Article
- GWAS on early sexual maturation across freshwater and seawater environments in domesticated Lochy strain of Atlantic salmon.Genetics, selection, evolution : GSE · 2026Article
- Genomic Basis and Climate Change Vulnerability of Migration Timing in Atlantic Salmon (Evolutionary applications · 2025Article
- Sex Bias in Autoimmunity: New Findings and New Opportunities.JID innovations : skin science from molecules to population health · 2025Review
- Large effect life-history genomic regions are associated with functional morphological traits in Atlantic salmon.G3 (Bethesda, Md.) · 2025Article
- Genomic evidence for fisheries-induced evolution in Eastern Baltic cod.Science advances · 2025Article
- Population Genetics of Atlantic Salmon (Ecology and evolution · 2025Article
- Genomic Insights Into Inbreeding and Adaptive Divergence of Trout Populations to Inform Genetic Rescue.Evolutionary applications · 2025Article
- Haemoglobin revisited: delineating population structure with the world's first molecular genetic marker used in fisheries research.Royal Society open science · 2025Article
- Whole-Genome Resequencing Reveals Polygenic Signatures of Directional and Balancing Selection on Alternative Migratory Life Histories.Molecular ecology · 2024Article
- A complex mechanism translating variation of a simple genetic architecture into alternative life histories.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Introgression affectsEvolutionary applications · 2024Article
- Variable parallelism in the genomic basis of age at maturity across spatial scales in Atlantic Salmon.Ecology and evolution · 2024Article
- Temporal allele frequency changes in large-effect loci reveal potential fishing impacts on salmon life-history diversity.Evolutionary applications · 2024Article
- Investigating structural variant, indel and single nucleotide polymorphism differentiation between locally adapted Atlantic salmon populations.Evolutionary applications · 2024Article
- Genetic parentage reveals the (un)natural history of Central Valley hatchery steelhead.Evolutionary applications · 2024Article
- Loss of Fshr Prevents Testicular Maturation in Atlantic Salmon (Salmo salar L.).Endocrinology · 2024Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wild and domesticated Atlantic salmon males display large variation for sea age at sexual maturation, which varies between 1-5 years. Previous studies have uncovered a genetic predisposition for variation of age at maturity with moderate heritability, thus suggesting a polygenic or complex nature of this trait. The aim of this study was to identify associated genetic loci, genes and ultimately specific sequence variants conferring sea age at maturity in salmon. We performed a genome wide association study (GWAS) using a pool sequencing approach (20 individuals per river and phenotype) of male salmon returning to rivers as sexually mature either after one sea winter (2009) or three sea winters (2011) in six rivers in Norway. The study revealed one major selective sweep, which covered 76 significant SNPs in which 74 were found in a 370 kb region of chromosome 25. Genotyping other smolt year classes of wild and domesticated salmon confirmed this finding. Genotyping domesticated fish narrowed the haplotype region to four SNPs covering 2386 bp, containing the vgll3 gene, including two missense mutations explaining 33-36% phenotypic variation. A single locus was found to have a highly significant role in governing sea age at maturation in this species. The SNPs identified may be both used as markers to guide breeding for late maturity in salmon aquaculture and in monitoring programs of wild salmon. Interestingly, a SNP in proximity of the VGLL3 gene in humans (Homo sapiens), has previously been linked to age at puberty suggesting a conserved mechanism for timing of puberty in vertebrates.
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