Evidence map›Paper›PMID 26551527›Full record

ArticlePloS one2015

Simultaneous [18F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer.

P Brandmaier, S Purz, K Bremicker, M Höckel, H Barthel, R Kluge, T Kahn, O Sabri, P Stumpp

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In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Diagnostic efficiency of whole-bodyCancer imaging : the official publication of the International Cancer Imaging Society · 2021
    Article
  13. Article
  14. Summary of the First ISMRM-SNMMI Workshop on PET/MRI: Applications and Limitations.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  15. Article
  16. Prognostic value of simultaneousEJNMMI research · 2018
    Article
  17. Article
  18. Article
  19. Article
  20. What's New in Imaging for Gynecologic Cancer?Current oncology reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

P BrandmaierDepartment of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.
S PurzDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
K BremickerDepartment of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.
M HöckelDepartment of Gynecology and Obstetrics, University Hospital Leipzig, Leipzig, Germany.
H BarthelDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
R KlugeDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
T KahnDepartment of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.
O SabriDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
P StumppDepartment of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPrevious non-simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using a simultaneous PET/MRI system which could lead to a better understanding of tumor biology and might play a role in early response assessment.

methodsWe included 31 patients with histologically confirmed primary (n = 14) or recurrent cervical cancer (n = 17) who underwent simultaneous whole-body 18F-FDG-PET/MRI comprising DWI. Image analysis was performed by a radiologist and a nuclear physician who identified tumor margins and quantified ADC and SUV. Pearson correlations were calculated to investigate the association between ADC and SUV.

results92 lesions were detected. We found a significant inverse correlation between SUVmax and ADCmin (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUVmean and ADCmin (r = -0.403, p = 0.03). In recurrent local tumors we found correlations for SUVmax and ADCmin (r = -0.747, p = 0.002) and SUVmean and ADCmin (r = -0.773, p = 0.001). Associations for recurrent metastases were not significant (p>0.05).

conclusionsOur study demonstrates the feasibility of fast and reliable measurement of SUV and ADC with simultaneous PET/MRI. In patients with cervical cancer we found significant inverse correlations for SUV and ADC which could play a major role for further tumor characterization and therapy decisions.

Indexed as

AdultAgedDiffusion Magnetic Resonance ImagingFemaleFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedMiddle AgedMultimodal ImagingNeoplasm Recurrence, LocalPositron-Emission TomographyProspective StudiesRadiopharmaceuticalsUterine Cervical NeoplasmsFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID26551527
PMCPMC4638340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.