ArticleJournal of affective disorders2016
Resting-state functional network connectivity in prefrontal regions differs between unmedicated patients with bipolar and major depressive disorders.
Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Altered functional activity in bipolar disorder: A comprehensive review from a large-scale network perspective.Brain and behavior · 2021Pooled it
- Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disordersJournal of psychiatry & neuroscience : JPN · 2018Pooled it
- Identifying transdiagnostic neurobiomarkers for precision major psychiatric disordersJournal of translational internal medicine · 2026Article
- Kernel-Transformed Functional Connectivity Entropy Reveals Network Dedifferentiation in Bipolar Disorder.Brain sciences · 2026Article
- Prefrontal activation in bipolar and unipolar depression patients in the letter fluency tasks and category fluency tasks: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2025Article
- Distinct connectivity patterns in bipolar and unipolar depression: a functional connectivity multivariate pattern analysis study.BMC neuroscience · 2024Article
- Abnormal large-scale brain functional network dynamics in social anxiety disorder.CNS neuroscience & therapeutics · 2024Article
- Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Patterns of Neural Network Functional Connectivity Associated With Mania/Hypomania and Depression Risk in 3 Independent Young Adult Samples.JAMA psychiatry · 2024Article
- Large-scale brain functional network abnormalities in social anxiety disorder.Psychological medicine · 2023Article
- Brain-based graph-theoretical predictive modeling to map the trajectory of transdiagnostic symptoms of anhedonia, impulsivity, and hypomania from the human functional connectome.Research square · 2023Article
- Altered language network lateralization in euthymic bipolar patients: a pilot study.Translational psychiatry · 2022Article
- Aberrant Subnetwork and Hub Dysconnectivity in Adult Bipolar Disorder: A Multicenter Graph Theory Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Multivariate Gaussian Copula Mutual Information to Estimate Functional Connectivity with Less Random Architecture.Entropy (Basel, Switzerland) · 2022Article
- Disrupted intrinsic functional brain topology in patients with major depressive disorder.Molecular psychiatry · 2021Article
- Effective Connectivity between Major Nodes of the Limbic System, Salience and Frontoparietal Networks Differentiates Schizophrenia and Mood Disorders from Healthy Controls.Journal of personalized medicine · 2021Article
- Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study.European archives of psychiatry and clinical neuroscience · 2021Article
- Mood disorders disrupt the functional dynamics, not spatial organization of brain resting state networks.NeuroImage. Clinical · 2021Article
- Disrupted Regional Homogeneity in Melancholic and Non-melancholic Major Depressive Disorder at Rest.Frontiers in psychiatry · 2021Article
- Resting State Functional Connectivity Associated With Sahaja Yoga Meditation.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDifferentiating bipolar disorder (BD) from major depressive disorder (MDD) often poses a major clinical challenge, and optimal clinical care can be hindered by misdiagnoses. This study investigated the differences between BD and MDD in resting-state functional network connectivity (FNC) using a data-driven image analysis method.
methodsIn this study, fMRI data were collected from unmedicated subjects including 13 BD, 40 MDD and 33 healthy controls (HC). The FNC was calculated between functional brain networks derived from fMRI using group independent component analysis (ICA). Group comparisons were performed on connectivity strengths and other graph measures of FNC matrices.
resultsStatistical tests showed that, compared to MDD, the FNC in BD was characterized by more closely connected and more efficient topological structures as assessed by graph theory. The differences were found at both the whole-brain-level and the functional-network-level in prefrontal networks located in the dorsolateral/ventrolateral prefrontal cortex (DLPFC, VLPFC) and anterior cingulate cortex (ACC). Furthermore, interconnected structures in these networks in both patient groups were negatively associated with symptom severity on depression rating scales. LIMITATIONS: As patients were unmedicated, the sample sizes were relatively small, although they were comparable to those in previous fMRI studies comparing BD and MDD.
conclusionsOur results suggest that the differences in FNC of the PFC reflect distinct pathophysiological mechanisms in BD and MDD. Such findings ultimately may elucidate the neural pathways in which distinct functional changes can give rise to the clinical differences observed between these syndromes.
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