ReviewToxicology2016
Mechanisms of divalent metal toxicity in affective disorders.
Review in Toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Short- and Long-Term Effects of a Single Exposure to Gadoteric Acid in Healthy Rats-Gadolinium, Iron and Other Metal Accumulation in Kidney and Brain.International journal of molecular sciences · 2026Article
- Mixed exposure to lead, methylmercury, and cadmium aggravates spatial memory deficits via dopamine signaling pathways in the mouse hippocampus.Frontiers in public health · 2026Article
- Article
- Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity.BMC pharmacology & toxicology · 2024Article
- Particulate matter from car exhaust alters function of human iPSC-derived microglia.Particle and fibre toxicology · 2024Article
- Common and Trace Metals in Alzheimer's and Parkinson's Diseases.International journal of molecular sciences · 2023Review
- Mitochondrial Dysfunction, Oxidative Stress, and Therapeutic Strategies in Diabetes, Obesity, and Cardiovascular Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Pb(II) coordination to the nonclassical zinc finger tristetraprolin: retained function with an altered fold.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023Article
- Asymptomatic Lead Poisoning in a Pediatric Patient.Cureus · 2023Article
- Parkinson's Disease and the Metal-Microbiome-Gut-Brain Axis: A Systems Toxicology Approach.Antioxidants (Basel, Switzerland) · 2021Review
- Plant-Based Dietary Practices and Socioeconomic Factors That Influence Anemia in India.Nutrients · 2021Review
- Identifying sensitive windows of airborne lead exposure associated with behavioral outcomes at age 12.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- The urban lead (Pb) burden in humans, animals and the natural environment.Environmental research · 2021Review
- Evaluation of transgenerational effects caused by metals as environmental pollutants in Daphnia magna.Environmental monitoring and assessment · 2020Article
- Prenatal toxic metal mixture exposure and newborn telomere length: Modification by maternal antioxidant intake.Environmental research · 2020Article
- The Role of Fe, Zn, and Cu in Pregnancy.Biomolecules · 2020Review
- Article
- Heavy Metals Exposure and Alzheimer's Disease and Related Dementias.Journal of Alzheimer's disease : JAD · 2020Review
- Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress.Antioxidants & redox signaling · 2018Review
- SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Metals are required for proper brain development and play an important role in a number of neurobiological functions. The divalent metal transporter 1 (DMT1) is a major metal transporter involved in the absorption and metabolism of several essential metals like iron and manganese. However, non-essential divalent metals are also transported through this transporter. Therefore, altered expression of DMT1 can modify the absorption of toxic metals and metal-induced toxicity. An accumulating body of evidence has suggested that increased metal stores in the brain are associated with elevated oxidative stress promoted by the ability of metals to catalyze redox reactions, resulting in abnormal neurobehavioral function and the progression of neurodegenerative diseases. Metal overload has also been implicated in impaired emotional behavior, although the underlying mechanisms are not well understood with limited information. The current review focuses on psychiatric dysfunction associated with imbalanced metabolism of metals that are transported by DMT1. The investigations with respect to the toxic effects of metal overload on behavior and their underlying mechanisms of toxicity could provide several new therapeutic targets to treat metal-associated affective disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.