Evidence map›Paper›PMID 26550924›Full record

ArticlePsychological medicine2016

Disorder-specific and shared neurophysiological impairments of attention and inhibition in women with attention-deficit/hyperactivity disorder and women with bipolar disorder.

G Michelini, G L Kitsune, G M Hosang, P Asherson, G McLoughlin, J Kuntsi

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Psychological medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  9. Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

G MicheliniKing's College London,MRC Social,Genetic and Developmental Psychiatry Centre,Institute of Psychiatry,Psychology and Neuroscience,London,UK.
G L KitsuneKing's College London,MRC Social,Genetic and Developmental Psychiatry Centre,Institute of Psychiatry,Psychology and Neuroscience,London,UK.
G M HosangDepartment of Psychology,Goldsmiths,University of London,London,UK.
P AshersonKing's College London,MRC Social,Genetic and Developmental Psychiatry Centre,Institute of Psychiatry,Psychology and Neuroscience,London,UK.
G McLoughlinKing's College London,MRC Social,Genetic and Developmental Psychiatry Centre,Institute of Psychiatry,Psychology and Neuroscience,London,UK.
J KuntsiKing's College London,MRC Social,Genetic and Developmental Psychiatry Centre,Institute of Psychiatry,Psychology and Neuroscience,London,UK.
King's College London · GBGoldsmiths University of London · GB

Funding

Medical Research Council G9817803
6 · The paper itself

Abstract

backgroundIn adults, attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) have certain overlapping symptoms, which can lead to uncertainty regarding the boundaries of the two disorders. Despite evidence of cognitive impairments in both disorders separately, such as in attentional and inhibitory processes, data on direct comparisons across ADHD and BD on cognitive-neurophysiological measures are as yet limited.

methodWe directly compared cognitive performance and event-related potential measures from a cued continuous performance test in 20 women with ADHD, 20 women with BD (currently euthymic) and 20 control women.

resultsThe NoGo-N2 was attenuated in women with BD, reflecting reduced conflict monitoring, compared with women with ADHD and controls (both p < 0.05). Both ADHD and BD groups showed a reduced NoGo-P3, reflecting inhibitory control, compared with controls (both p < 0.05). In addition, the contingent negative variation was significantly reduced in the ADHD group (p = 0.05), with a trend in the BD group (p = 0.07), compared with controls.

conclusionsThese findings indicate potential disorder-specific (conflict monitoring) and overlapping (inhibitory control, and potentially response preparation) neurophysiological impairments in women with ADHD and women with BD. The identified neurophysiological parameters further our understanding of neurophysiological impairments in women with ADHD and BD, and are candidate biomarkers that may aid in the identification of the diagnostic boundaries of the two disorders.

Indexed as

Inhibition, PsychologicalAdultAttentionAttention Deficit Disorder with HyperactivityBipolar DisorderCognition DisordersCuesEvoked PotentialsFemaleHumansMiddle AgedReaction TimeYoung AdultAttentionattention-deficit/hyperactivity disorderbipolar disorderconflict monitoringevent-related potentialsinhibitory control

Identifiers

PMID26550924
PMCPMC4697305
OpenAlexW2131785132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.