Evidence map›Paper›PMID 26550838›Full record

ArticlePloS one2015

Species-Specific Expression of Full-Length and Alternatively Spliced Variant Forms of CDK5RAP2.

John S Y Park, Marie-Katrina Lee, SungMyung Kang, Yan Jin, Songbin Fu, Jesusa L Rosales, Ki-Young Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

John S Y ParkDepartment of Cell Biology and Anatomy, Southern Alberta Cancer Research and Hotchkiss Brain Institutes, University of Calgary, Calgary, Alberta, Canada.
Marie-Katrina LeeDepartment of Cell Biology and Anatomy, Southern Alberta Cancer Research and Hotchkiss Brain Institutes, University of Calgary, Calgary, Alberta, Canada.
SungMyung KangDepartment of Cell Biology and Anatomy, Southern Alberta Cancer Research and Hotchkiss Brain Institutes, University of Calgary, Calgary, Alberta, Canada.
Yan JinLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Songbin FuLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Jesusa L RosalesDepartment of Biochemistry and Molecular Biology, Southern Alberta Cancer Research and Hotchkiss Brain Institutes, University of Calgary, Calgary, Alberta, Canada.
Ki-Young LeeDepartment of Cell Biology and Anatomy, Southern Alberta Cancer Research and Hotchkiss Brain Institutes, University of Calgary, Calgary, Alberta, Canada.
University of Calgary · CAHarbin Medical University · CN

Funding

Canadian Institutes of Health Research MOP-123400
6 · The paper itself

Abstract

CDK5RAP2 is one of the primary microcephaly genes that are associated with reduced brain size and mental retardation. We have previously shown that human CDK5RAP2 exists as a full-length form (hCDK5RAP2) or an alternatively spliced variant form (hCDK5RAP2-V1) that is lacking exon 32. The equivalent of hCDK5RAP2-V1 has been reported in rat and mouse but the presence of full-length equivalent hCDK5RAP2 in rat and mouse has not been examined. Here, we demonstrate that rat expresses both a full length and an alternatively spliced variant form of CDK5RAP2 that are equivalent to our previously reported hCDK5RAP2 and hCDK5RAP2-V1, repectively. However, mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms. Knowledge of this expression of different forms of CDK5RAP2 in human, rat and mouse is essential in selecting the appropriate model for studies of CDK5RAP2 and primary microcephaly but our findings further indicate the evolutionary divergence of mouse from the human and rat species.

Indexed as

Alternative SplicingAmino Acid SequenceAnimalsBase SequenceCell Cycle ProteinsDNAEvolution, MolecularExonsHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred BALB CMicrocephalyMolecular Sequence DataNerve Tissue ProteinsPhosphotransferasesCdk5r1 protein, ratCDK5RAP2 protein, humanCdk5rap2 protein, mouseCell Cycle ProteinsDNAIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsPhosphotransferases

Identifiers

PMID26550838
PMCPMC4638350
OpenAlexW2138087351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.