ArticleAmerican journal of translational research2015
MTRR silencing inhibits growth and cisplatin resistance of ovarian carcinoma via inducing apoptosis and reducing autophagy.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
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- LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1.Cell death & disease · 2024Article
- Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase.ACS central science · 2024Article
- Insight into autophagy in platinum resistance of cancer.International journal of clinical oncology · 2023Review
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- Rhein lysinate improves motor function in rats with spinal cord injury via inhibiting p38 MAPK pathway.The Kaohsiung journal of medical sciences · 2019Article
- Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia.Oncology letters · 2019Article
- Differential effects of ginkgol C17:1 on cisplatin-induced cytotoxicity: Protecting human normal L02 hepatocytes versus sensitizing human hepatoma HepG2 cells.Oncology letters · 2019Article
- Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma.Analytical cellular pathology (Amsterdam) · 2019Article
- Effects of ginkgol C17:1 on cisplatin-induced autophagy and apoptosis in HepG2 cells.Oncology letters · 2018Article
- Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats.Oncotarget · 2017Article
- Redox-Related Epigenetic Mechanisms in Glioblastoma: Nuclear Factor (Erythroid-Derived 2)-Like 2, Cobalamin, and Dopamine Receptor Subtype 4.Frontiers in oncology · 2017Article
- Tetrahydrocurcumin reduces oxidative stress-induced apoptosis via the mitochondrial apoptotic pathway by modulating autophagy in rats after traumatic brain injury.American journal of translational research · 2017Article
- Autophagy as an emerging therapy target for ovarian carcinoma.Oncotarget · 2016Review
- Autophagy regulates resistance of non-small cell lung cancer cells to paclitaxel.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Insulin-like growth factor 1 antagonizes lumbar disc degeneration through enhanced autophagy.American journal of translational research · 2016Article
- Colorectal cancer cells are resistant to anti-EGFR monoclonal antibody through adapted autophagy.American journal of translational research · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methionine synthase reductase (MTRR) is involved in the DNA synthesis and production of S-adenosylmethionine (SAM) and plays an important role in the carcinogenesis. However, the role of MTRR in the resistance of ovarian cancer (OC) to chemotherapy has yet to be elucidated. In order to investigate the clinical significance of MTRR in OC, MTRR expression was reduced by using the RNA interference technique, and therefore, and the tumor growth and cisplatin-resistance were evaluated in vitro and in vivo. Results showed MTRR expression increased orderly from normal tissues, benign ovarian tumor to OC tissue. MTRR over-expression in OC tissue was correlated with pathologic type (P=0.005), grade (P=0.037), FIGO stage (P=0.001), organ metastasis (P=0.009) and platinum resistance (P=0.038). MTRR silencing inhibited cell proliferation, cisplatin resistance and autophagy, and induced apoptosis of OC cells. In addition, MTRR silencing also affected the caspase expression as well as mTOR signaling pathway. Further, the tumor volume in MTRR-suppressed SKOV3/DDP mice treated with cisplatin significantly decreased when compared with controls (P<0.05). In summary, MTRR expression, which is increased in human OC, is related to the differentiation and cisplatin resistance of OC cells. MTRR silencing inhibits cell growth and cisplatin resistance by regulating caspase expression and mTOR signaling pathway in OC cells. It is suggested that MTRR may be a potential target for the therapy of OC.
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Identifiers
26550452PMC4626414W2428036158What OpenQuestion holds
Registered trials
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