ArticleInternational journal of clinical and experimental medicine2015
Leptin receptor gene polymorphisms and risk of hypertension: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- Effect of leptin concentrations and leptin receptor gene polymorphisms on the outcome of renal transplantation.Archives of medical science : AMS · 2024Article
- Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients.The pharmacogenomics journal · 2020Article
- Variability in the leptin receptor gene and other risk factors for post-transplant diabetes mellitus in renal transplant recipients.Annals of medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the relationship between the polymorphisms of leptin receptor gene and hypertension.
methodsMeta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein".
resultsFifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene polymorphism was significantly higher in hypertension patients than in control (OR=1.36, 95% CI=1.23-1.51, P<0.00001). However, no statistically significant difference was found in Lys109Arg polymorphism between hypertension patients and control (OR=0.99, 95% CI=0.85-1.16, P=0.91).
conclusionGln223Arg, but not Lys109Arg gene polymorphism, is higher in hypertension patients, suggesting that patients with Gln223Arg allele carry a higher risk to develop hypertension.
Indexed as
Identifiers
26550411PMC4613096W2194089347What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.