Different regulation of Toll-like receptor 4 expression on blood CD14(+) monocytes by simvastatin in patients with sepsis and severe sepsis.

Huanzhang Shao, Cunzhen Wang, Wenliang Zhu, Xiaopei Huang, Zhisong Guo, Huifeng Zhang, Bingyu Qin

Abstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Macrophage CD14 impacts immune defenses against influenza virus in allergic hosts.Microbial pathogenesis · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Huanzhang ShaoDepartment of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.

Cunzhen WangDepartment of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.

Wenliang ZhuDepartment of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.

Xiaopei HuangDepartment of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.

Zhisong GuoDepartment of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.

Huifeng ZhangDepartment of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.

Bingyu QinDepartment of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.

Henan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have demonstrated that regulation of Toll-like receptor 4 (TLR4) surface expression levels on blood CD14(+) monocytes by simvastatin treatment in patient with sepsis is different from that in patients with severe sepsis. In patients with sepsis simvastatin treatment statistically significantly decreased TLR4 surface expression level on blood CD14(+) monocytes, while in patients with severe sepsis simvastatin treatment had no significant influence on TLR4 surface expression level on blood CD14(+) monocytes. The changes of plasma interleukin-6 (IL-6) induced by simvastatin in patients with sepsis and severe sepsis were similar with that of TLR4. Our results indicated simvastatin treatment differently influenced inflammation process in patients with sepsis and severe sepsis, which might partially explain the discrepancy, presented by previous trials, about the therapeutic effects of simvastatin treatment in patients with sepsis and severe sepsis.

Indexed as

interleukin-6Sepsissevere sepsissimvastatinToll-like receptor 4

Identifiers

PMID26550333

PMCPMC4613018

OpenAlexW2122118643

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.