Correlation of NGX6 expression with clinicopathologic features and prognosis in colon cancer.

Jidong Xiao, Yuanquan Zhou, Bo Liu

Abstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 43% of its field

1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
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5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jidong XiaoDepartment of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

Yuanquan ZhouDepartment of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

Bo LiuDepartment of Orthopedics, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim was to explore the correlation of NGX6 expression with clinicopathological features and prognosis in colon cancer.

methodsClinicopathological feature of 145 patients with colon cancer were analyzed.NGX6 expression was measured using immunohistochemistry methods. The correlation of NGX6 expression with clinicopathological features and prognosis were assessed.

resultsAmong 145 cases of colon cancer, NGX6 positive expression were found in 76 (52.4%) cases and NGX6 negative expression were found in 69 (47.6%) cases. The expression of NGX6 was closely associated with size tumor, lymph node metastasis and TNM stage (P=0.002, 0.012, and 0.039, respectively). Kaplan-Meier analysis showed that NGX6 negative expression was associated with shorter disease-free survival (DFS) (P=0.029) and overall survival (OS) (P=0.015). Multivariate survival analysis demonstrated that NGX6 expression was the important independent prognostic factor for colon cancer (P=0.022).

conclusionNGX6 is involved in the invasion and metastasis activity of colon cancer. NGX6 could may be applied as a novel and promising prognostic marker for colon cancer.

Indexed as

Colon cancermetastasisnasopharyngeal carcinoma associated gene 6 (NGX6)pathologyprognosis

Identifiers

PMID26550308

PMCPMC4612993

OpenAlexW2194755738

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.