ArticleInternational journal of clinical and experimental medicine2015
Relationship between lipoprotein lipase gene polymorphism and hemorrhagic stroke in a Chinese population.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS): A meta-analysis.Medicine · 2018Pooled it
- Article
- Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence.Biomedicines · 2022Review
- Lipoprotein lipase gene polymorphisms as risk factors for stroke: a computational and meta-analysis.Iranian journal of basic medical sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between lipoprotein lipase (LPL) gene polymorphism and cerebral hemorrhage in a Chinese population.
methodThis study was based on the case-control study, PCR-RELP and sequencing method were utilized for genotyping. LPL gene Hind III polymorphism was detected both in 300 patients with cerebral hemorrhage (CH group) and in 300 healthy control subjects (control group). Blood lipid level and blood glucose were detected at the same time.
resultOur results showed that G allele frequency was significant lower in the CH group than that in the control group (OR=0.611; 95% CI: 0.427-0.876, P=0.001). We also found both GG (OR=0.543, 95% CI: 0.233-0.988; P=0.041) and TG (OR=0.609, 95% CI: 0.387-0.959, P=0.032) genotype were frequent in the control group than that in the CH group. TG level of the groups who carry TT genotype were much higher than that of the groups carrying TG+GG genotype (P<0.05). By means of adjusting age, hypertension and hyperglycemia, logistic multivariate regression analysis revealed that LPL Hind III G allele might be a protective factor (OR=0.601, 95% CI: 0.231-0.876; P=0.001) in the present study.
conclusionIt is suggested that LPL Hind III G allelic mutation might be a protective factor against cerebral hemorrhage disease in Chinese population.
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Identifiers
26550299PMC4612984W2103096384What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.