ArticleInternational journal of clinical and experimental medicine2015
Baseline quantitative hepatitis B core antibody could strongly predict survival for patients with hepatocellular carcinoma undergoing transarterial chemoembolization.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Review
- Europium (III) chelate microparticle-based lateral flow immunoassay strips for rapid and quantitative detection of antibody to hepatitis B core antigen.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The investigation regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) in HCC patients after transarterial chemoembolization (TACE) is rare. The aim of this study was to determine the prognostic significance of anti-HBc in HCC patients after TACE. A total of 66 HCC patients with complete data and treated with TACE in Nanfang Hospital, Southern Medical University were retrospectively analyzed. Univariate analyses were performed for 20 pretreatment variables and those with a P value less than 0.05 by univariate analysis were subjected to Cox proportional hazards model. Among the 66 HCC patients, the 0.5-, 1-, and 2-year overall survival rates were 92.42%, 50.00%, and 21.21%, respectively. We defined 11.88 S/CO, with a maximum sum of sensitivity and specificity, as the optimal cut-off value of baseline anti-HBc level to predict the OS rate in HCC patients after TACE. Univariate and multivariate analyses revealed that baseline anti-HBc level, AFP level and vascular invasion were the only three independent significant prognostic factors of overall survival (P = 0.001, 0.020 and 0.010, respectively). We demonstrated that baseline anti-HBc level, combining AFP level and vascular invasion, might be a novel biomarker for predicting the survival of HCC patients after TACE.
Indexed as
Identifiers
26550290PMC4612975What OpenQuestion holds
Registered trials
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