ArticleInternational journal of clinical and experimental medicine2015
Lower serum bilirubin concentration in patients with migraine.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03387306 (Reduced Serum Bilirubin Levels in Patients With Normal-tension Glaucoma), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reduced Serum Bilirubin Levels in Patients With Normal-tension Glaucoma
Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Review
- The Association between Serum Total Bilirubin and Severe Headaches or Migraine in American Adults.Current neurovascular research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBilirubin has been seen as a toxic waste product since it is product of heme metabolism. It's the latest in a series of studies showed that the concentration of serum bilirubin is associated with various diseases such as multiple sclerosis, hypertension and cardiovascular diseases (CVD). However, no study to investigate the association between serum bilirubin and migraine, thus, our aim is to investigate the association between serum bilirubin and migraine.
methodsSerum samples were collected from 120 patients with migraine and 128 healthy individuals, serum total bilirubin (Tbil), serum direct bilirubin (Dbil) and serum indirect bilirubin (Ibil) concentration were measured to this study.
resultsTbil, Dbil and Ibil concentration were significantly lower in patients with migraine than healthy controls. Tbil, Dbil and Ibil concentration also were lower in patients with migraine compared with healthy controls when serum bilirubin concentration further was grouped by gender.
conclusionsWe found evidence that lower serum bilirubin in patients with migraine, serum bilirubin may be useful markers to estimate neurogenic inflammation in patients with migraine.
Indexed as
Identifiers
26550273PMC4612958W2173408913What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.