ArticleInternational journal of clinical and experimental medicine2015
Co-transplantation of hippocampal neural stem cells and astrocytes and microvascular endothelial cells improve the memory in ischemic stroke rat.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid-Beta Pathology in Alzheimer's Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in genetically modified neural stem cell therapy for central nervous system injury and neurological diseases.Stem cell research & therapy · 2024Review
- New role of astrocytes in neuroprotective mechanisms after ischemic stroke.Arquivos de neuro-psiquiatria · 2023Review
- Applications of Induced Pluripotent Stem Cell-Derived Glia in Brain Disease Research and Treatment.Handbook of experimental pharmacology · 2023Review
- Donor-derived vasculature is required to support neocortical cell grafts after stroke.Stem cell research · 2022Article
- Pluripotent Stem Cells for Brain Repair: Protocols and Preclinical Applications in Cortical and Hippocampal Pathologies.Frontiers in neuroscience · 2019Review
- Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, bothNeural regeneration research · 2018Article
- Combined acupuncture andNeural regeneration research · 2018Article
- Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area.Journal of visualized experiments : JoVE · 2017Article
- A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke.Stem cells international · 2017Review
- Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury.Molecular medicine reports · 2016Article
- Proliferation and Glia-Directed Differentiation of Neural Stem Cells in the Subventricular Zone of the Lateral Ventricle and the Migratory Pathway to the Lesions after Cortical Devascularization of Adult Rats.BioMed research international · 2016Article
- Therapeutic Potential of Astrocyte Transplantation.Cell transplantationReview
- Ginkgo Biloba Extract in Ophthalmic and Systemic Disease, With a Focus on Normal-Tension Glaucoma.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeural stem cells (NSCs) are promising for ischemia stroke because they can replace damaged or lost cells. However, the adult central nervous system (CNS) does not provide an optimal microenvironment for exogenous NSCs to survive, proliferation and differentiation. We established a co-transplantation system with NSCs and astrocyte and brain microvascular endothelial cells (BMECs) to explore whether it can improve the memory ability in ischemic stroke rat.
methodsAfter building the ischemic stroke in 50 rats by middle cerebral artery occlusion and reperfusion (MCAO/R), transplantation of NSCs and astrocyte and BMECs were performed with different combination.
resultsLaser doppler flowmetry and MRI were used to detect the ischemia of the model and 42 rats survived for the Morris water-maze test. The test shows that co-transplantation with the three different cells together can improve memory deficits in MCAO/R rat and it is the most effect group. Grafting with two cells have more effect in memory improving than one cell while transplanting NSC alone has no obvious effect on memory improving.
conclusionsIn NSC niche, astrocytes and BMECs are the most important cells to regulate and interaction with NSCs. Co-transplantation NSCs with astrocyte and BMECs can improve the memory ability in ischemia rat, which maybe the result of microenvironment improve by the astrocyte and BMECs.
Indexed as
Identifiers
26550233PMC4612918W2192999605What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.