Evidence map›Paper›PMID 26550208›Full record

ArticleInternational journal of clinical and experimental medicine2015

Angiotensinogen polymorphism and ischemic stroke risk.

Huan Bao, Jun-Jie Hao, Yu-Mei Yang, Xia-Hong Xu, Yue Wang, Lian Zuo, Jing Lu, Jing Zhang, Yue Zhang, Si-Yi Xu and 3 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Huan BaoDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Jun-Jie HaoDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Yu-Mei YangDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Xia-Hong XuDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Yue WangDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Lian ZuoDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Jing LuDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Jing ZhangDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Yue ZhangDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Si-Yi XuDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Xuan WangDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Ying LiDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.
Gang LiDepartment of Neurology, Shanghai East Hospital Shanghai 200123, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The angiotensinogen M235T polymorphism was associated with ischemic stroke risk. However, the results were controversial. Thus, a meta-analysis was conducted. NCBI, Medline, Web of Science and Embase databases were systematically searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. There was a significant association between angiotensinogen M235T polymorphism and ischemic stroke risk (OR = 1.69; 95% CI, 1.35-2.11; P < 0.001). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with ischemic stroke in Asian (OR = 1.85; 95% CI, 1.45-2.35; P < 0.001). In the age subgroup, we found that angiotensinogen M235T polymorphism could increase both early-onset ischemic stroke risk (OR = 1.88; 95% CI, 1.33-2.43; P < 0.001) and late-onset ischemic stroke risk (OR = 1.20; 95% CI, 1.01-1.39; P = 0.04). This meta-analysis suggested that angiotensinogen M235T polymorphism was associated with ischemic stroke.

Indexed as

angiotensinogengeneticIschemic strokemeta-analysis

Identifiers

PMID26550208
PMCPMC4612893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.