ArticleInternational journal of clinical and experimental medicine2015
The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- The Prevalence of Symptomatic Knee Osteoarthritis in Relation to Age, Sex, Area, Region, and Body Mass Index in China: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2020Pooled it
- Pooled it
- Pooled it
- The Genetic Markers of Knee Osteoarthritis in Women from Russia.Biomedicines · 2024Article
- Genetics in Cartilage Lesions: Basic Science and Therapy Approaches.International journal of molecular sciences · 2020Review
- Association betweenOncotarget · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that the double von Willebrandfactor domain A (DVWA) gene polymorphisms may be associated with osteoarthritis (OA) risk. However, some studies yielded conflicting results. Therefore, we conducted a comprehensive meta-analysis to identify the association of DVWA gene polymorphisms and the susceptibility to OA. We conducted a systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI) and Wangfang databases up to May 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. Statistical analyses were performed with STATA 11.0 software. In total, 11 studies from five articles with 13,579 subjectswere included in this meta-analysis. The overall results indicated that there was a significant association between DVWA rs7639618 polymorphism and OA susceptibility observed in dominant and co-dominant models. In the subgroup analysis, we found that DVWA gene rs7639618 and rs11718863 polymorphism was associated with OA risk in Asians (GG+GA vs. AA: OR=1.34, P<0.001; G vs. A: OR=1.29, P=0.019). Furthermore, for rs7639618, the dominant (GG+GA) and heterozygote (GA) may strongly increase the knee OA susceptibility (GG+GA vs. AA: OR=1.27, P<0.001), especially in Asians. In addition, as for rs11718863, a trend of increased knee OA risk was found in Asians (TT+TA vs. AA: OR=1.54, P<0.001). In conclusion, the meta-analysis results suggested that DVWArs7639618 and rs11718863 polymorphisms may increase the risk of knee OA susceptibility in Asians, but not in Caucasians. However, no significant association between SNP rs7639618 and rs11718863 and hip OA risk was identified.
Indexed as
Identifiers
26550167PMC4612852What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.