ArticleInternational journal of clinical and experimental medicine2015
Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- New Angiogenic Regulators Produced by TAMs: Perspective for Targeting Tumor Angiogenesis.Cancers · 2021Review
- Genetic Variations in Prostaglandin EInternational journal of molecular sciences · 2021Article
- Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region.Journal of human genetics · 2020Article
- Article
- Non-random distribution of gastric cancer susceptible loci on human chromosomes.EXCLI journal · 2018Article
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Authors and funding
5 authors.
Funding
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Abstract
The association between cyclooxygenase-2 (COX-2) -1195G>A (rs689466) polymorphism and cancer risk has been extensively explored. However, the results of previous studies remain controversial. To address this gap, we performed an updated meta-analysis of fifty-eight studies involving a total of 50,672 subjects. Searching of PubMed and Embase databases was performed for publications on the association between COX-2 -1195G>A polymorphism and the risk of cancer. Statistical correlation was identified between COX-2 -1195G>A variants and overall cancer risk in five genetic models. In a sub-group analysis based on cancer type, significant association between COX-2 -1195G>A polymorphism and increased risk of gastric cancer, pancreatic cancer, hepatocellular carcinoma and other cancers was found. In a sub-group analysis by ethnicity, increased cancer risk was observed among Asians instead of Caucasians, Africans and mixed populations. Furthermore, in a sub-group analysis based on cancer system, increased cancer risk was found in digestive system cancer and other system cancer. Non-parametric "trim-and-fill" method was harnessed as a sensitivity analysis method and the results suggested our findings reliable. In summary, the results of our meta-analysis highlight that COX-2 -1195G>A polymorphism may be a risk factor for cancer.
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26550156PMC4612841What OpenQuestion holds
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