ArticleInternational journal of clinical and experimental medicine2015
Arachidonic acid attenuates learning and memory dysfunction induced by repeated isoflurane anesthesia in rats.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- The Janus Face of Isoflurane: A Dose-Age-Response Model of Cognitive Impact.Biomolecules · 2026Review
- Evidence of Active-Forgetting Mechanisms? Blocking Arachidonic Acid Release May Slow Forgetting of Sensitization ineNeuro · 2024Article
- RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice.Neurobiology of disease · 2023Article
- Neobaicalein prevents isoflurane anesthesia-induced cognitive impairment in neonatal mice via regulating CREB1.Clinics (Sao Paulo, Brazil) · 2023Article
- Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway.Life (Basel, Switzerland) · 2022Article
- Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling.Neuroscience bulletin · 2021Article
- Overexpression of miR-133b protects against isoflurane-induced learning and memory impairment.Experimental and therapeutic medicine · 2021Article
- Article
- Effect of Isoflurane Exposure with Administration of Polyunsaturated Fatty Acids on Cognition in Developing Rats.Turkish journal of anaesthesiology and reanimation · 2020Article
- Effect of chronic administration of arachidonic acid on the performance of learning and memory in aged rats.Food & nutrition research · 2019Article
- Maternal Supplementation With Avocado (Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to explore the effects of arachidonic acid (ARA) on learning and memory dysfunction in rats exposed to repeated isoflurane anesthesia and the underlying mechanisms. Fifty rats were randomly divided into five groups: sham control group, isoflurane group, low dose ARA + isoflurane group, moderate dose ARA + isoflurane group, high dose ARA + isoflurane group. The Morris water maze test was performed to assess learning and memory function and the hippocampus tissues were obtained for biochemical analysis. The results showed that administration of ARA improved learning and memory deficit induced by repeated isofluane anesthesia in Morris water maze test and in a dose-dependent manner. Additionally, ARA increased the activities of choline acetyl transferase (ChAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the levels of acetycholine (Ach) and γ-amino-butyric acid (GABA), whereas decreased the activity of acetylcholine esterase (AchE), the content of glutamate (Glu) and malondialdehyde (MDA), and the radio of Glu/GABA. Meanwhile, ARA elevated the ratio of Bcl-2/Bax and inhibited the activity of caspase-3. In conclusion, ARA has potential therapeutic value in alleviating isoflurane-induced learning and memory impairment. The mechanism might be involved in regulating the cholinergic and Glu/GABA regulatory system, decreasing oxidative damage and inhibiting cell apoptosis.
Indexed as
Identifiers
26550146PMC4612831W2193882879What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.