ArticleInternational journal of clinical and experimental medicine2015
CD14 gene-159C/T polymorphism and coronary artery disease: a meta-analysis involving 4467 subjects.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- FVII gene R353Q polymorphism and coronary heart disease: a meta-analysis including 3258 subjects.Journal of thrombosis and thrombolysis · 2021Pooled it
- Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.Lipids in health and disease · 2019Pooled it
- ALDH2 gene G487A polymorphism and coronary artery disease: a meta-analysis including 5644 participants.Journal of cellular and molecular medicine · 2018Pooled it
- Particulate matter exposure is associated with inflammatory gene methylation in obese subjects.Environmental research · 2017Article
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cluster of differentiation antigen 14 (CD14) gene-159C/T polymorphism has been implied to be associated with coronary artery disease (CAD) susceptibility. However, the separate studies results are still conflicting between each other. OBJECTIVE AND
methodsTo investigate the relationship between CD14 gene-159C/T polymorphism and CAD, a meta-analysis including 4467 subjects from 7 individual studies was performed. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals.
resultsThere was a significant association between CD14 gene -159C/T polymorphism and CAD in the whole population under allelic (OR: 1.280, 95% CI: 1.000-1.630, P=0.05), recessive (OR: 1.760, 95% CI: 1.120-2.750, P=0.01), homozygous (OR: 1.693, 95% CI: 1.008-2.843, P=0.046), and additive genetic models (OR: 1.278, 95% CI: 1.000-1.633, P=0.050). No significant association was found between them under dominant (OR: 0.580, 95% CI: 0.310-1.110, P=0.10) and heterozygous genetic models (OR: 1.334, 95% CI: 0.870-2.045, P=0.186). In the subgroup analysis, a significant association was detected in Chinese population (P<0.05), while there was no significant association in the Caucasian subgroup (P>0.05).
conclusionsCD14 gene -159C/T polymorphism was significantly associated with CAD susceptibility, particularly in the Chinese population. The person with T allele of CD14 gene -159C/T polymorphism might predispose to CAD. There was no distinct association between them in the Caucasian subgroup.
Indexed as
Identifiers
26550125PMC4612810What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.