Evidence map›Paper›PMID 26550102›Full record

ReviewInternational journal of clinical and experimental medicine2015

Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis.

Luliang Liu, Jinhuan Sun, Guolin Li, Boyu Gu, Xiaolong Wang, Huirong Chi, Fulin Guo

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017
    Review
  7. The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke.International journal of molecular sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luliang LiuDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Jinhuan SunDepartment of Periodontology, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Guolin LiDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Boyu GuDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Xiaolong WangDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Huirong ChiDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Fulin GuoDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results. Therefore, we performed a meta-analysis of case-control study to evaluate the association of MMP-12-82A>G polymorphism and cancer risk.

methodsA systematic literature search was conducted among PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI) and Wangfang databases updated on May 1st, 2015. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between this polymorphism and cancer risk.

resultsA total of seventeen case-control studies with 7,450 cases and 7,348 controls were identified and analyzed. Overall, there was no statistically significant association between MMP-12-82A>G polymorphism and increased risk of cancer under all genetic models. Subgroup analysis by ethnicity observed that there is no strong relationship between MMP-12-82A>G polymorphism and cancer risk among Asian and European populations. Furthermore, stratified analysis based on the source of control revealed no statistically significant association between MMP-12-82A>G polymorphism and cancer risk either in hospital-based or population-based studies. However, when we stratified analysis based on cancer type, significant association was found in ovarian cancer, but not in other types of cancer.

conclusionThis meta-analysis suggests that MMP-12-82A>G polymorphism is not significantly associated with overall cancer risk. However, MMP-12-82A>G polymorphism may increase the susceptibility to ovarian cancer.

Indexed as

cancer riskMatrix metalloproteinases-12meta-analysispolymorphism

Identifiers

PMID26550102
PMCPMC4612787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.