ArticleNuclear medicine and molecular imaging2015
Prognostic Value of Metabolic Tumor Volume on (11)C-Methionine PET in Predicting Progression-Free Survival in High-Grade Glioma.
Article in Nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- MRI combined with PET-CT of different tracers to improve the accuracy of glioma diagnosis: a systematic review and meta-analysis.Neurosurgical review · 2019Pooled it
- Prognostic Value of the Metabolic and Volumetric Parameters ofAJNR. American journal of neuroradiology · 2018Pooled it
- Differentiating high-grade glioma progression from treatment-related changes with dynamic [European radiology · 2023Article
- Prognostic value of 11C-methionine volume-based PET parameters in IDH wild type glioblastoma.PloS one · 2022Article
- Potential role of functional imaging in predicting outcome for patients treated with carbon ion therapy: a review.The British journal of radiology · 2021Article
- Effect of quantitative values on shortened acquisition duration in brain tumorEJNMMI physics · 2021Article
- Prognostic Significance of Metabolic Parameters byCancers · 2021Article
- Met-PET uptake index for total tumor resection: identification ofNeurosurgical review · 2021Article
- Nose-to-brain delivery: exploring newer domains for glioblastoma multiforme management.Drug delivery and translational research · 2020Review
- Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models.European journal of nuclear medicine and molecular imaging · 2020Article
- Prognostic Value of MTV, SUVmax and the T/N Ratio of PET/CT in Patients with Glioma: A Systematic Review and Meta-Analysis.Journal of Cancer · 2019Article
- The Emerging Role of Amino Acid PET in Neuro-Oncology.Bioengineering (Basel, Switzerland) · 2018Review
- Prognostic Utility of TotalGastroenterology · 2018Article
- Visual and semiquantitative 11C-methionine PET: an independent prognostic factor for survival of newly diagnosed and treatment-naïve gliomas.Neuro-oncology · 2018Article
- Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-correctedEJNMMI research · 2017Article
- Response assessment of bevacizumab therapy in GBM with integrated 11C-MET-PET/MRI: a feasibility study.European journal of nuclear medicine and molecular imaging · 2017Article
- Prognostic value of molecular and imaging biomarkers in patients with supratentorial glioma.European journal of nuclear medicine and molecular imaging · 2017Article
- Prognostic Molecular and Imaging Biomarkers in Primary Glioblastoma.Clinical nuclear medicine · 2017Article
- Imaging of Myocardial Ischemia-Reperfusion Injury Using Sodium [Molecular imaging · 2017Article
- Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction.Theranostics · 2016Article
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7 authors.
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Abstract
purposeC-11 methionine (MET) PET is commonly used for diagnosing high-grade glioma (HGG). Recently, volumetric analysis has been widely applied to oncologic PET imaging. In this study, we investigated the prognostic value of metabolic tumor volume (MTV) on MET PET in HGG.
methodsA total of 30 patients with anaplastic astrocytoma (n = 12) and glioblastoma multiforme (n = 18) who underwent MET PET before treatment (surgery followed by chemo-radiotherapy) were retrospectively enrolled. Maximal tumor-to-normal brain ratio (TNRmax, maximum tumor activity divided by mean of normal tissue) and MTV (volume of tumor tissue that shows uptake >1.3-fold of mean uptake in normal tissue) were measured on MET PET. Adult patients were classified into two subgroups according to Radiation Therapy Oncology Group Recursive Partitioning Analysis (RTOG RPA) classification. Prognostic values of TNRmax, MTV and clinicopathologic factors were evaluated with regard to progression-free survival (PFS).
resultsMedian PFS of all patients was 7.9 months (range 1.0-53.8 months). In univariate analysis, MTV (cutoff 35 cm(3)) was a significant prognostic factor for PFS (P = 0.01), whereas TNRmax (cutoff 3.3) and RTOG RPA class were not (P = 0.80 and 0.61, respectively). Treatment of surgical resection exhibited a borderline significance (P = 0.06). In multivariate analysis, MTV was the only independent prognostic factor for PFS (P = 0.03).
conclusionMTV on MET PET is a significant and independent prognostic factor for PFS in HGG patients, whereas TNRmax is not. Thus, performing volumetric analysis of MET PET is recommended in HGG for better prognostication.
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