ArticleJournal of micromechanics and microengineering : structures, devices, and systems2015
Mixing in microfluidic devices and enhancement methods.
Article in Journal of micromechanics and microengineering : structures, devices, and systems, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed.
- Curvature-driven passive mixing in three-dimensional conical helix micromixers.Microsystems & nanoengineering · 2026Article
- Solid Dispersion Characteristics of an Oscillatory Microfluidic Mixer: An Experimental and Numerical Investigation.Micromachines · 2026Article
- Machine Learning-Driven Capillary Microfluidic Design Automation for Programmable Gradient Generation and Antimicrobial Testing.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Integrated microfluidic device for DNA extraction using electric valves.Scientific reports · 2026Article
- Pulse Driven Injection in an Additive-Manufactured Microchannel for Rapid Mixing of Stratified Concurrent Flow and On-Demand Droplet Generation.Micromachines · 2026Article
- Numerical Investigation of a Mitochondria-Inspired Micromixer for Enhanced Mixing.Micromachines · 2026Article
- Advancing non-faradaic impedance biosensors: sensitivity enhancement strategies using microfluidics, multiscale labeling, and CMOS technology.Microsystems & nanoengineering · 2026Review
- Recent Advances in MEMS Actuators for Microfluidic Applications: Emerging Designs, Multiphysics Modeling, and Performance Optimization.Micromachines · 2026Review
- Generalized blood vessel models for magnetic nanoparticle-based oncology: geometric and microfluidic properties.Scientific reports · 2026Article
- Hybrid passive micromixer using combined traditional microfabrication and 3D printing for gold nanoparticle synthesis.PloS one · 2026Article
- Present and future of smart functional materials as actuators in microfluidic devices.Lab on a chip · 2025Review
- Prospects and problems in enzyme immobilization methodology: comprehensive review.Biophysical reviews · 2025Review
- New 3D Spiral Microfluidic Platform Tested for FeMolecules (Basel, Switzerland) · 2025Article
- A Novel Single-Layer Microfluidic Device for Dynamic Stimulation, Culture, and Imaging of Mammalian Cells.Biosensors · 2025Article
- Nanovesicles and Human Skin Interaction: A Comparative Ex-Vivo Study.Nanomaterials (Basel, Switzerland) · 2025Article
- Enhanced Micromixing Using Surface Acoustic Wave Devices: Fundamentals, Designs, and Applications.Micromachines · 2025Review
- Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived fromPharmaceutics · 2025Article
- Design and Investigation of a Passive-Type Microfluidics Micromixer Integrated with an Archimedes Screw for Enhanced Mixing Performance.Micromachines · 2025Article
- Advances in PLGA-Based Drug Delivery Systems for Glioblastoma Treatment.International journal of nanomedicine · 2025Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mixing in microfluidic devices presents a challenge due to laminar flows in microchannels, which result from low Reynolds numbers determined by the channel's hydraulic diameter, flow velocity, and solution's kinetic viscosity. To address this challenge, novel methods of mixing enhancement within microfluidic devices have been explored for a variety of applications. Passive mixing methods have been created, including those using ridges or slanted wells within the microchannels, as well as their variations with improved performance by varying geometry and patterns, by changing the properties of channel surfaces, and by optimization via simulations. In addition, active mixing methods including microstirrers, acoustic mixers, and flow pulsation have been investigated and integrated into microfluidic devices to enhance mixing in a more controllable manner. In general, passive mixers are easy to integrate, but difficult to control externally by users after fabrication. Active mixers usually take efforts to integrate within a device and they require external components (e.g. power sources) to operate. However, they can be controlled by users to a certain degree for tuned mixing. In this article, we provide a general overview of a number of passive and active mixers, discuss their advantages and disadvantages, and make suggestions on choosing a mixing method for a specific need as well as advocate possible integration of key elements of passive and active mixers to harness the advantages of both types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.