Evidence map›Paper›PMID 26549881›Full record

ArticleTrends in neurosciences2015

Ineffective VTA Disinhibition in Protracted Opiate Withdrawal.

Michel Barrot

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. nNOS-expressing neurons in the mPFC mediate depression-related behaviors in mice through pPVT-mPFC projections.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Anhedonia as a key clinical feature in the maintenance and treatment of opioid use disorder.Clinical psychological science : a journal of the Association for Psychological Science · 2019
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michel BarrotInstitut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, 5 rue Blaise Pascal, 67084 Strasbourg, France; Université de Strasbourg, Strasbourg, France. Electronic address: mbarrot@inci-cnrs.unistra.fr.
Institut des Neurosciences Cellulaires et Intégratives · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, Kaufling and Aston-Jones showed that, under protracted opiate withdrawal, control of dopamine activity by the tail of the ventral tegmental area shifts from a bidirectional influence towards one-way inhibition. Beyond dysphoric states accompanying withdrawal, these results may also impact research on depression and individual differences in coping and affect.

Indexed as

AnimalsDopaminergic NeuronsMaleMorphineNarcoticsSubstance Withdrawal SyndromeVentral Tegmental AreaMorphineNarcoticsDepressionDopamineMorphineRMTgtVTAWithdrawal

Identifiers

PMID26549881
OpenAlexW2166449983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.