ArticleScientific reports2015
Revisiting the reference genomes of human pathogenic Cryptosporidium species: reannotation of C. parvum Iowa and a new C. hominis reference.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- The genome sequence of the gastric gland parasite,iScience · 2026Article
- Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite.Cell host & microbe · 2025Article
- Stage-specific expression and divergent functions of two insulinase-like proteases associated with host infectivity in Cryptosporidium.PLoS neglected tropical diseases · 2025Article
- Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes.Nature communications · 2024Article
- Exploring the impact of digestive physicochemical parameters of adults and infants on the pathophysiology of Cryptosporidium parvum using the dynamic TIM-1 gastrointestinal model.Gut pathogens · 2024Article
- Sequence introgression from exogenous lineages underlies genomic and biological differences among Cryptosporidium parvum IOWA lines.Water research · 2024Article
- Phylogenomic reconstruction ofbioRxiv : the preprint server for biology · 2024Article
- High subtelomeric GC content in the genome of a zoonoticMicrobial genomics · 2023Article
- Multiple introductions and recombination events underlie the emergence of a hyper-transmissible Cryptosporidium hominis subtype in the USA.Cell host & microbe · 2023Article
- An update onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Splice-site identification for exon prediction using bidirectional LSTM-RNN approach.Biochemistry and biophysics reports · 2022Article
- Global Population Genomics of Two Subspecies of Cryptosporidium hominis during 500 Years of Evolution.Molecular biology and evolution · 2022Article
- Long-read assembly and comparative evidence-based reanalysis ofGenome research · 2022Article
- Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research.Frontiers in cellular and infection microbiology · 2022Review
- Review
- Challenges forGenes · 2021Review
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- Comparative genomics revealed adaptive admixture inMicrobial genomics · 2021Article
- Comparative analyses and structural insights of new class glutathione transferases in Cryptosporidium species.Scientific reports · 2020Article
- Common occurrence of Cryptosporidium hominis in children attending day-care centers in Medellin, Colombia.Parasitology research · 2020Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptosporidium parvum and C. hominis are the most relevant species of this genus for human health. Both cause a self-limiting diarrhea in immunocompetent individuals, but cause potentially life-threatening disease in the immunocompromised. Despite the importance of these pathogens, only one reference genome of each has been analyzed and published. These two reference genomes were sequenced using automated capillary sequencing; as of yet, no next generation sequencing technology has been applied to improve their assemblies and annotations. For C. hominis, the main challenge that prevents a larger number of genomes to be sequenced is its resistance to axenic culture. In the present study, we employed next generation technology to analyse the genomic DNA and RNA to generate a new reference genome sequence of a C. hominis strain isolated directly from human stool and a new genome annotation of the C. parvum Iowa reference genome.
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