ReviewPulmonary pharmacology & therapeutics2015
Role of the dorsal medulla in the neurogenesis of airway protection.
Review in Pulmonary pharmacology & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Modeling synaptic interactions between mammalian breathing and swallowing central pattern generators.Biological cybernetics · 2026Article
- Acupuncture for Poststroke Dysphagia: An NTS-Centered Hypothesis-Generating Framework Linking the Brainstem Swallowing Network, Neuroimmune Regulation, and Vagal Anti-Inflammatory Signaling.Brain and behavior · 2026Review
- The central regulatory network of cough: a cornerstone of cough management.Journal of thoracic disease · 2025Review
- Dendritic alterations precede age-related dysphagia and nucleus ambiguus motor neuron death.The Journal of physiology · 2025Article
- Construction and validation of an ultrasound-based nomogram model for predicting dysphagia in patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2025Article
- Dendritic morphology of motor neurons and interneurons within the compact, semicompact, and loose formations of the rat nucleus ambiguus.Frontiers in cellular neuroscience · 2024Article
- Detection of respiratory frequency rhythm in human alpha phase shifts: topographic distributions in wake and drowsy states.Frontiers in physiology · 2024Article
- Amygdalar involvement in respiratory dysfunction.Frontiers in physiology · 2024Review
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.Journal of neuropathology and experimental neurology · 2023Article
- A New Therapeutic Approach for Dystussia and Atussia in Neurogenic Dysphagia: Effect of Aerosolized Capsaicin on Peak Cough Flow.Dysphagia · 2022Article
- The Physiology and Maintenance of Respiration: A Narrative Review.Pain and therapy · 2020Review
- Timing of Endotracheal Intubation in Patients with Fulminant Enterovirus 71 Infection.Medicina (Kaunas, Lithuania) · 2020Article
- Improving Accuracy of Brainstem MRI Volumetry: Effects of Age and Sex, and Normalization Strategies.Frontiers in neuroscience · 2020Article
- Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.Comprehensive Physiology · 2019Review
- Diaphragm muscle function following midcervical contusion injury in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Carotid chemoreceptors tune breathing via multipath routing: reticular chain and loop operations supported by parallel spike train correlations.Journal of neurophysiology · 2018Article
- Central Respiration and Mechanical Ventilation in the Gating of Swallow With Breathing.Frontiers in physiology · 2018Article
- Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The dorsal medulla encompassing the nucleus of the tractus solitarius (NTS) and surrounding reticular formation (RF) has an important role in processing sensory information from the upper and lower airways for the generation and control of airway protective behaviors. These behaviors, such as cough and swallow, historically have been studied in isolation. However, recent information indicates that these and other airway protective behaviors are coordinated to minimize risk of aspiration. The dorsal medullary neural circuits that include the NTS are responsible for rhythmogenesis for repetitive swallowing, but previous models have assigned a role for this portion of the network for coughing that is restricted to monosynaptic sensory processing. We propose a more complex NTS/RF circuit that controls expression of swallowing and coughing and the coordination of these behaviors. The proposed circuit is supported by recordings of activity patterns of selected neural elements in vivo and simulations of a computational model of the brainstem circuit for breathing, coughing, and swallowing. This circuit includes separate rhythmic sub-circuits for all three behaviors. The revised NTS/RF circuit can account for the mode of action of antitussive drugs on the cough motor pattern, as well as the unique coordination of cough and swallow by a meta-behavioral control system for airway protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.