ArticleMicrobiome2015
Chemostat culture systems support diverse bacteriophage communities from human feces.
Article in Microbiome, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Gut bacteriophage dynamics during fecal microbial transplantation in subjects with metabolic syndrome.Gut microbesTrial
- Dietary yacon concentrate reshapes microbial-metabolite crosstalk to inhibit colorectal cancer.NPJ science of food · 2026Article
- Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material.iScience · 2024Article
- Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments.Microbiome · 2024Article
- Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice.Nature communications · 2024Article
- Phage Mediated Biocontrol: A Promising Green Solution for Sustainable Agriculture.Indian journal of microbiology · 2024Review
- Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice.bioRxiv : the preprint server for biology · 2023Article
- Bacteriophage-Mediated Perturbation of Defined Bacterial Communities in anMicrobiology spectrum · 2022Article
- Adintoviruses: a proposed animal-tropic family of midsize eukaryotic linear dsDNA (MELD) viruses.Virus evolution · 2021Article
- Potential Applications of Human Viral Metagenomics and Reference Materials: Considerations for Current and Future Viruses.Applied and environmental microbiology · 2020Review
- 5 challenges in understanding the role of the virome in health and disease.PLoS pathogens · 2020Review
- Article
- Shining Light on Human Gut Bacteriophages.Frontiers in cellular and infection microbiology · 2020Review
- The Virome of Cerebrospinal Fluid: Viruses Where We Once Thought There Were None.Frontiers in microbiology · 2019Article
- Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota.British journal of cancer · 2018Article
- Shared and Distinct Features of Human Milk and Infant Stool Viromes.Frontiers in microbiology · 2018Article
- Review
- The healthy human microbiome.Genome medicine · 2016Review
- Natural mummification of the human gut preserves bacteriophage DNA.FEMS microbiology letters · 2016Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost human microbiota studies focus on bacteria inhabiting body surfaces, but these surfaces also are home to large populations of viruses. Many are bacteriophages, and their role in driving bacterial diversity is difficult to decipher without the use of in vitro ecosystems that can reproduce human microbial communities.
resultsWe used chemostat culture systems known to harbor diverse fecal bacteria to decipher whether these cultures also are home to phage communities. We found that there are vast viral communities inhabiting these ecosystems, with estimated concentrations similar to those found in human feces. The viral communities are composed entirely of bacteriophages and likely contain both temperate and lytic phages based on their similarities to other known phages. We examined the cultured phage communities at five separate time points over 24 days and found that they were highly individual-specific, suggesting that much of the subject-specificity found in human viromes also is captured by this culture-based system. A high proportion of the community membership is conserved over time, but the cultured communities maintain more similarity with other intra-subject cultures than they do to human feces. In four of the five subjects, estimated viral diversity between fecal and cultured communities was highly similar.
conclusionsBecause the diversity of phages in these cultured fecal communities have similarities to those found in humans, we believe these communities can serve as valuable ecosystems to help uncover the role of phages in human microbial communities.
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