ArticleEnvironmental microbiology reports2016
The Pseudomonas aeruginosa AmrZ C-terminal domain mediates tetramerization and is required for its activator and repressor functions.
Article in Environmental microbiology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- The bacteriophage transcription factor Gp53 suppresses cell division and regulates Pseudomonas aeruginosa physiology.Communications biology · 2026Article
- Molecular insights into small RNA-mediated regulation of biofilm formation and multidrug resistance in Pseudomonas aeruginosa under zinc oxide nanoparticle exposure.Journal, genetic engineering & biotechnology · 2026Article
- Article
- Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level.Microbiology (Reading, England) · 2023Review
- Adaption ofMicroorganisms · 2023Review
- The Alginate and Motility Regulator AmrZ is Essential for the Regulation of the Dispersion Response bymSphere · 2022Article
- Genetic Regulation of Alginate Production inFrontiers in microbiology · 2022Review
- The function of small RNA inPeerJ · 2022Article
- Activation of the Cell Wall Stress Response inMicroorganisms · 2020Article
- Biofilm dispersion.Nature reviews. Microbiology · 2020Review
- Untethering and Degradation of the Polysaccharide Matrix Are Essential Steps in the Dispersion Response ofJournal of bacteriology · 2020Article
- Evolutionary Plasticity of AmrZ Regulation inmSphere · 2018Article
- A novel inducible prophage from the mycosphere inhabitant Paraburkholderia terrae BS437.Scientific reports · 2017Article
- Pseudomonas aeruginosa AmrZ Binds to Four Sites in the algD Promoter, Inducing DNA-AmrZ Complex Formation and Transcriptional Activation.Journal of bacteriology · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pseudomonas aeruginosa is an important bacterial opportunistic pathogen, presenting a significant threat towards individuals with underlying diseases such as cystic fibrosis. The transcription factor AmrZ regulates expression of multiple P. aeruginosa virulence factors. AmrZ belongs to the ribbon-helix-helix protein superfamily, in which many members function as dimers, yet others form higher order oligomers. In this study, four independent approaches were undertaken and demonstrated that the primary AmrZ form in solution is tetrameric. Deletion of the AmrZ C-terminal domain leads to loss of tetramerization and reduced DNA binding to both activated and repressed target promoters. Additionally, the C-terminal domain is essential for efficient AmrZ-mediated activation and repression of its targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.