Evidence map›Paper›PMID 26549629›Full record

ArticleSchizophrenia research2015

Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample.

Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D'Angelo, Larry J Seidman, Sarah Gumlak, April Kim, Kristen A Woodberry, Ashley Rober, Sahil Tembulkar, Kelsey Graber and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joseph Gonzalez-HeydrichBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA. Electronic address: Joseph.Gonzalez-Heydrich@childrens.harvard.edu.
Michelle Bosquet EnlowBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA.
Eugene D'AngeloBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA.
Larry J SeidmanHarvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA; Beth Israel Deaconess Medical Center, Department of Psychiatry, Commonwealth Research Center, 75 Fenwood Road, Boston, MA 02115, USA; Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, USA.
Sarah GumlakBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
April KimBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Kristen A WoodberryHarvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA; Beth Israel Deaconess Medical Center, Department of Psychiatry, Commonwealth Research Center, 75 Fenwood Road, Boston, MA 02115, USA.
Ashley RoberBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Sahil TembulkarBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Kelsey GraberBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Kyle O'DonnellBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Hesham M HamodaBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA.
Kara KimballBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Alexander RotenbergBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Neurology, 25 Shattuck Street, Boston, MA 02115, USA.
Lindsay M ObermanE.P. Bradley Hospital and Warren Alpert Medical School, Brown University, Neuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, 1011 Veterans Memorial Parkway, East Providence, RI 02915, USA.
Alvaro Pascual-LeoneHarvard Medical School, Department of Neurology, 25 Shattuck Street, Boston, MA 02115, USA; Beth Israel Deaconess Medical Center, Division of Cognitive Neurology and Berenson-Allen Center, 330 Brookline Avenue, Boston, MA 02115, USA.
Matcheri S KeshavanHarvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA; Beth Israel Deaconess Medical Center, Department of Psychiatry, Commonwealth Research Center, 75 Fenwood Road, Boston, MA 02115, USA.
Frank H DuffyBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Department of Neurology, 25 Shattuck Street, Boston, MA 02115, USA.

Funding

Cortical Plasticity in Autism Spectrum DisordersR01MH100186 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROTENBERG, ALEXANDER · 2014 to 2018
$2.2M
Innovative Intervention for Reducing Stress Reactivity and Risk for PsychosisK23MH102358 · NIMH · MAINEHEALTH · PI WOODBERRY, KRISTEN ANNE · 2014 to 2017
$722k
NIMH NIH HHS 1R01MH100186NIMH NIH HHS K23 MH102358NIMH NIH HHS R01 MH100186NIMH NIH HHS U01 MH08198-06A1
6 · The paper itself

Abstract

backgroundThe N100 is a negative deflection in the surface EEG approximately 100 ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic symptoms. This phenomenon has received little attention in pediatric populations.

methodThis cross-sectional study compared the N100 response measured via the average EEG response at the left medial frontal position FC1 to 150 sinusoidal tones in participants ages 5 to 17 years with a CHR syndrome (n=29), a psychotic disorder (n=22), or healthy controls (n=17).

resultsLinear regression analyses that considered potential covariates (age, gender, handedness, family mental health history, medication usage) revealed decreasing N100 amplitude with increasing severity of psychotic symptomatology from healthy to CHR to psychotic level.

conclusionsLongitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change.

Indexed as

Acoustic StimulationAdolescentAnalysis of VarianceChildChild, PreschoolElectroencephalographyEvoked Potentials, AuditoryFemaleHumansLinear ModelsMalePsychiatric Status Rating ScalesSchizophreniaClinical high riskEarly onsetN100PsychosisSchizophreniaSuperior temporal cortex

Identifiers

PMID26549629
PMCPMC4821005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.