Evidence map›Paper›PMID 26549599›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016

Anxiety is associated with increased risk of dementia in older Swedish twins.

Andrew J Petkus, Chandra A Reynolds, Julie Loebach Wetherell, William S Kremen, Nancy L Pedersen, Margaret Gatz

Open access · greenAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
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  13. Lifestyle Adjustment: Influential Risk Factors in Cognitive Aging.Advances in experimental medicine and biology · 2023
    Article
  14. Are All Anxieties Created Equal? Stress-related Networks and Anxiety Phenotypes in Old Age.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Andrew J PetkusDepartment of Psychology, University of Southern California, Los Angeles, CA, USA. Electronic address: petkus@usc.edu.
Chandra A ReynoldsDepartment of Psychology, University of California, Riverside, CA, USA.
Julie Loebach WetherellPsychology Service, VA San Diego Healthcare System; Department of Psychiatry, University of California, San Diego, CA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, CA, USA; VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Nancy L PedersenDepartment of Psychology, University of Southern California, Los Angeles, CA, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Margaret GatzDepartment of Psychology, University of Southern California, Los Angeles, CA, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
University of Southern California · USKarolinska Institutet · SEUniversity of California, Riverside · USUniversity of California, San Diego · USVA San Diego Healthcare System · US

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
DEMENTIA IN TWINSR01AG008724 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 1990 to 2002
$1.4M
Anxiety and Cognition in Swedish Twins: Genetic and Environmental InfluencesF31AG042218 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETKUS, ANDREW JOHN · 2012 to 2013
$49k
GENETIC AND ENVIRONMENTAL INFLUENCES IN BEHAVIORAL AGINGR01AG004563 · NIA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI MCCLEARN, GERALD E · 1985 to 1988
–
NIA NIH HHS 1F31AG042218-01NIA NIH HHS F31 AG042218NIA NIH HHS R01 AG008724NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG04563NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG08724NIA NIH HHS R01 AG10175
6 · The paper itself

Abstract

introductionWe asked whether anxiety is associated with prospective risk of dementia, and the extent to which genetic influences mediate this association.

methodsNondemented twins (n = 1082) from the Swedish Adoption Twin Study of Aging completed an assessment of anxiety symptoms in 1984 and were followed for 28 years.

resultsBaseline anxiety score, independent of depressive symptoms, was significantly associated with incident dementia over follow-up (hazard ratio [HR] = 1.04; 95% confidence interval [CI] = 1.01-1.06). There was 48% increased risk of becoming demented for those who had experienced high anxiety at any time compared with those who had not. In co-twin analyses, the association between anxiety symptoms and dementia was greater for dizygotic (HR = 1.11; 95% CI = 1.02-1.20) compared with monozygotic twins (HR = 1.06; 95% CI = 0.95-1.20), indicating genetic mediation. DISCUSSION: Anxiety symptoms were associated with increased risk of dementia. Genetic factors common to dementia and anxiety partially mediated this association.

Indexed as

AgedAnxietyDementiaFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedProspective StudiesPsychiatric Status Rating ScalesRiskSwedenTwins, DizygoticTwins, MonozygoticAnxietyDementiaDepressionGeneticsTwins

Identifiers

PMID26549599
PMCPMC4841698
OpenAlexW2131386294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.