ArticleCell reports2015
Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Invasion by exogenous RNA: cellular defense strategies and implications for RNA inference.Marine life science & technology · 2023Review
- Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery.Frontiers in cell and developmental biology · 2022Review
- Ancient viral integrations in marsupials: a potential antiviral defence.Virus evolution · 2021Article
- Synthetic Virology: Building Viruses to Better Understand Them.Cold Spring Harbor perspectives in medicine · 2020Review
- A Requirement for Argonaute 4 in Mammalian Antiviral Defense.Cell reports · 2020Article
- Review
- Slicing and dicing viruses: antiviral RNA interference in mammals.The EMBO journal · 2019Review
- Harnessing host-virus evolution in antiviral therapy and immunotherapy.Clinical & translational immunology · 2019Review
- MicroRNA-Attenuated Virus Vaccines.Non-coding RNA · 2018Review
- Homologous recombination is an intrinsic defense against antiviral RNA interference.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Influenza A virus-derived siRNAs increase in the absence of NS1 yet fail to inhibit virus replication.RNA (New York, N.Y.) · 2018Article
- Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes.PLoS genetics · 2018Article
- Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function.Cell reports · 2018Article
- Review
- MicroRNA-Based Attenuation of Influenza Virus across Susceptible Hosts.Journal of virology · 2018Article
- The Immune Responses of the Animal Hosts of West Nile Virus: A Comparison of Insects, Birds, and Mammals.Frontiers in cellular and infection microbiology · 2018Review
- MicroRNA-134 regulates poliovirus replication by IRES targeting.Scientific reports · 2017Article
- Article
- Questioning antiviral RNAi in mammals.Nature microbiology · 2017Article
- SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology.Cell host & microbe · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Although the intrinsic antiviral cell defenses of many kingdoms utilize pathogen-specific small RNAs, the antiviral response of chordates is primarily protein based and not uniquely tailored to the incoming microbe. In an effort to explain this evolutionary bifurcation, we determined whether antiviral RNAi was sufficient to replace the protein-based type I interferon (IFN-I) system of mammals. To this end, we recreated an RNAi-like response in mammals and determined its effectiveness to combat influenza A virus in vivo in the presence and absence of the canonical IFN-I system. Mammalian antiviral RNAi, elicited by either host- or virus-derived small RNAs, effectively attenuated virus and prevented disease independently of the innate immune response. These data find that chordates could have utilized RNAi as their primary antiviral cell defense and suggest that the IFN-I system emerged as a result of natural selection imposed by ancient pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.