Evidence map›Paper›PMID 26548914›Full record

ReviewNature reviews. Microbiology2015

Twenty years of bacterial genome sequencing.

Nicholas J Loman, Mark J Pallen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 1 synthesis or guideline pooled it, 339 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Comparative genomics of crucian carp-isolatedFrontiers in microbiology · 2026
    Article
  11. A genomic view of Earth's biomes.Nature reviews. Genetics · 2026
    Review
  12. Review
  13. Article
  14. Detection of Live Shiga Toxin-ProducingInternational journal of molecular sciences · 2025
    Article
  15. Rapid Detection ofMicroorganisms · 2025
    Article
  16. Review
  17. Short-sighted evolution of virulence for invasive gut microbes: From hypothesis to tests.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Article
  20. Article

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nicholas J LomanInstitute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.
Mark J PallenMicrobiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
University of Birmingham · GBUniversity of Warwick · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E011179/1Medical Research Council MR/J014370/1Medical Research Council MR/L015080/1Medical Research Council MR/M501621/1
6 · The paper itself

Abstract

Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades of bacterial genome sequencing, which have been marked by three revolutions: whole-genome shotgun sequencing, high-throughput sequencing and single-molecule long-read sequencing. We summarize the social history of sequencing and its impact on our understanding of the biology, diversity and evolution of bacteria, while also highlighting spin-offs and translational impact in the clinic. We look forward to a 'sequencing singularity', where sequencing becomes the method of choice for as-yet unthinkable applications in bacteriology and beyond.

Indexed as

Genome, BacterialDNA, BacterialHistory, 20th CenturyHistory, 21st CenturyHumansMolecular EpidemiologyMolecular TypingSequence Analysis, DNADNA, Bacterial

Identifiers

PMID26548914
OpenAlexW2116617401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.