ArticlePhysiology & behavior2016
The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats.
Article in Physiology & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Reducing nicotine exposure results in weight gain in smokers randomised to very low nicotine content cigarettes.Tobacco control · 2017Trial
- Sex-dependent differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice.Journal of neurochemistry · 2025Article
- Substitutability of nicotine and sucrose in rats: A behavioral economic analysis.Pharmacology, biochemistry, and behavior · 2023Article
- Investigating Behavioral and Neuronal Changes in Adolescent Mice Following Prenatal Exposure to Electronic Cigarette (E-Cigarette) Vapor Containing Nicotine.Brain sciences · 2023Article
- Withdrawal: A key consideration in evaluating whether highly processed foods are addictive.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Anatabine, Nornicotine, and Anabasine Reduce Weight Gain and Body Fat through Decreases in Food Intake and Increases in Physical Activity.Journal of clinical medicine · 2022Article
- Stimulus functions of nicotine.Advances in pharmacology (San Diego, Calif.) · 2022Article
- Tobacco withdrawal increases junk food intake: The role of the endogenous opioid system.Drug and alcohol dependence · 2021Article
- Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement.Behavioural brain research · 2021Article
- Effects of acute and chronic nicotine on catecholamine neurons of the nucleus of the solitary tract.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats.Psychopharmacology · 2018Article
- Effects of isolated tobacco alkaloids and tobacco products on deprivation-induced food intake and meal patterns in rats.Pharmacology, biochemistry, and behavior · 2018Article
- Self-administered nicotine differentially impacts body weight gain in obesity-prone and obesity-resistant rats.Physiology & behavior · 2017Article
- Self-Administered Nicotine Suppresses Body Weight Gain Independent of Food Intake in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Carbohydrate intake, preference, and taste thresholds may be altered in current and former cigarette smokers, which may mediate weight gain and risk for obesity in individuals who quit smoking. Attempts to model these effects in rodents have primarily used noncontingent nicotine administration. The purpose of this research was to characterize changes in chow and sucrose intake in rats during a 23-h access model of i.v. nicotine self-administration (NSA), in which rats lever-pressed for chow, sucrose, and nicotine under concurrent fixed-ratio (FR) 1 schedules. Male rats were assigned to one of three groups that differed in food and drug availability. The Nicotine C+S group had concurrent access to nicotine, chow, and sucrose. The Saline C+S group had access to saline, chow, and sucrose. The Nicotine C-Only group had access to nicotine and chow, but not sucrose. Changes in food intake and weight gain were assessed during baseline, NSA, and nicotine withdrawal (i.e., saline extinction). Weight gain was significantly slowed during NSA and increased during withdrawal, but did not differ between the nicotine groups. NSA produced a significant decrease in both chow and sucrose intake. Gradual tolerance to nicotine's effects on sucrose, but not chow intake, occurred. During withdrawal, chow and sucrose intake increased, with a larger percent increase in sucrose intake compared to chow. The proportion of total food intake from sucrose was greater at the end of withdrawal compared to baseline, indicating a history of nicotine intake changed dietary preference. Combined, these results indicate that sucrose intake is more resistant to nicotine's appetite suppressant effects and withdrawal from nicotine produces a greater increase in sweet food intake alongside general increases in chow intake. Changes in overall food intake in current and ex-smokers may lead to increased risk for obesity and other health problems, potentially limiting the benefit of quitting smoking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.