Evidence map›Paper›PMID 26548486›Full record

ArticleThe Journal of investigative dermatology2015

CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?

Taihao Quan, Andrew Johnston, Johann E Gudjonsson, Gary J Fisher

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Taihao QuanDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Andrew JohnstonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Gary J FisherDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: gjfisher@med.umich.edu.

Funding

Transforming Growth Factor-Beta (TGF-b) Signaling in Photoaged and ChronologicallR01AG019364 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FISHER, GARY J, QUAN, TAIHAO · 2002 to 2014
$3.0M
Collagenase degradation in extracellular matrix in agingR01AG025186 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FISHER, GARY J · 2006 to 2010
$1.8M
CYR61-a novel potential mediator of photoaged human skinR01ES014697 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QUAN, TAIHAO · 2007 to 2010
$1.7M
Regulation of Extracellular Matrix Homeostatsis in Skin AgingR01AG031452 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FISHER, GARY J · 2009 to 2013
$1.5M
Role of the Psoriasis Associated IL23R Risk Variants on Th17 Biology and FunctionK08AR060802 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2011 to 2015
$636k
Biologic Activities of IL-36 Cytokines in PsoriasisK01AR064765 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHNSTON, ANDREW · 2013 to 2017
$506k
NIAMS NIH HHS K01 AR064765NIAMS NIH HHS K01-AR064765NIAMS NIH HHS K08-AR060802NIA NIH HHS R01 AG019364NIA NIH HHS R01-AG019364NIA NIH HHS R01 AG025186NIA NIH HHS R01-AG025186NIA NIH HHS R01 AG031452NIA NIH HHS R01-AG031452NIEHS NIH HHS R01 ES014697NIEHS NIH HHS R01-ES-ES014697
6 · The paper itself

Abstract

The complex pathogenesis of psoriasis is still not fully understood. The study by Sun et al. (2015) suggests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of psoriasis, and thus targeting CCN1 represents a potential therapeutic strategy in its treatment.

Indexed as

AnimalsCysteine-Rich Protein 61FemaleHumansInflammation MediatorsPsoriasisCysteine-Rich Protein 61Inflammation Mediators

Identifiers

PMID26548486
PMCPMC4641044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.