Evidence map›Paper›PMID 26548414›Full record

ArticleNeuroscience2015

Antihyperalgesic effect of tetrodotoxin in rat models of persistent muscle pain.

P Alvarez, J D Levine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Nociceptor Overexpression of NaThe journal of pain · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Sodium channels and pain: from toxins to therapies.British journal of pharmacology · 2018
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

P AlvarezDepartment of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA.
J D LevineDepartment of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Electronic address: jon.levine@ucsf.edu.
University of California, San Francisco · US

Funding

Acute-to-Chronic Transition in Ergonomic Muscle Pain: Nociceptor MechanismsR01AR063312 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2013 to 2022
$6.5M
NIAMS NIH HHS AR063312NIAMS NIH HHS R01 AR063312
6 · The paper itself

Abstract

Persistent muscle pain is a common and disabling symptom for which available treatments have limited efficacy. Since tetrodotoxin (TTX) displays a marked antinociceptive effect in models of persistent cutaneous pain, we tested its local antinociceptive effect in rat models of muscle pain induced by inflammation, ergonomic injury and chemotherapy-induced neuropathy. While local injection of TTX (0.03-1 μg) into the gastrocnemius muscle did not affect the mechanical nociceptive threshold in naïve rats, exposure to the inflammogen carrageenan produced a marked muscle mechanical hyperalgesia, which was dose-dependently inhibited by TTX. This antihyperalgesic effect was still significant at 24h. TTX also displayed a robust antinociceptive effect on eccentric exercise-induced mechanical hyperalgesia in the gastrocnemius muscle, a model of ergonomic pain. Finally, TTX produced a small but significant inhibition of neuropathic muscle pain induced by systemic administration of the cancer chemotherapeutic agent oxaliplatin. These results indicate that TTX-sensitive sodium currents in nociceptors play a central role in diverse states of skeletal muscle nociceptive sensitization, supporting the suggestion that therapeutic interventions based on TTX may prove useful in the treatment of muscle pain.

Indexed as

AnalgesicsAnimalsDisease Models, AnimalDose-Response Relationship, DrugHyperalgesiaMaleMotor ActivityMuscle, SkeletalMyalgiaNociceptive PainOrganoplatinum CompoundsOxaliplatinPain ThresholdRats, Sprague-DawleyTetrodotoxinTouchAnalgesicsOrganoplatinum CompoundsOxaliplatinTetrodotoxinclinical trialsdelayed-onset muscle sorenessinflammationmechanical hyperalgesianeuropathic muscle painvoltage-dependent sodium channels

Identifiers

PMID26548414
PMCPMC4679288
OpenAlexW2132589158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.